Human FGFR2/BBDS/BEK ORF/cDNA clone-Lentivirus plasmid (NM_022970)

Cat. No.: pGMLV000611
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human FGFR2/BBDS/BEK Lentiviral expression plasmid for FGFR2 lentivirus packaging, FGFR2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLV000611
Gene Name FGFR2
Accession Number NM_022970
Gene ID 2263
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 2469 bp
Gene Alias BBDS,BEK,BFR-1,CD332,CEK3,CFD1,ECT1,JWS,K-SAM,KGFR,TK14,TK25
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Biosimilar GMP-Bios-ab-057 Pre-Made Bemarituzumab biosimilar, Whole mAb, Anti-FGFR2 Antibody: Anti-BBDS/BEK/BFR-1/CD332/CEK3/CFD1/ECT1/JWS/K-SAM/KGFR/TK14/TK25 therapeutic antibody
    Biosimilar GMP-Bios-INN-737 Pre-Made Aprutumab Ixadotin Biosimilar, Whole Mab Adc, Anti-Fgfr2 Antibody: Anti-BBDS/BEK/BFR-1/CD332/CEK3/CFD1/ECT1/JWS/K-SAM/KGFR/TK14/TK25 therapeutic antibody Drug Conjugate
    Biosimilar GMP-Bios-ab-031 Pre-Made Aprutumab biosimilar, Whole mAb ADC, Anti-FGFR2 Antibody: Anti-BBDS/BEK/BFR-1/CD332/CEK3/CFD1/ECT1/JWS/K-SAM/KGFR/TK14/TK25 therapeutic antibody
    Target Antibody GM-Tg-g-T58454-Ab Anti-FGFR2/ BBDS/ BEK monoclonal antibody
    Target Antigen GM-Tg-g-T58454-Ag FGFR2 VLP (virus-like particle)
    Cytokine cks-Tg-g-GM-T58454 fibroblast growth factor receptor 2 (FGFR2) protein & antibody
    ORF Viral Vector pGMLP005638 Human FGFR2 Lentivirus plasmid
    ORF Viral Vector pGMLV000611 Human FGFR2 Lentivirus plasmid
    ORF Viral Vector pGMLV001565 Human FGFR2 Lentivirus plasmid
    ORF Viral Vector pGMLV001576 Human FGFR2 Lentivirus plasmid
    ORF Viral Vector vGMLP005638 Human FGFR2 Lentivirus particle
    ORF Viral Vector vGMLV000611 Human FGFR2 Lentivirus particle
    ORF Viral Vector vGMLV001565 Human FGFR2 Lentivirus particle
    ORF Viral Vector vGMLV001576 Human FGFR2 Lentivirus particle


    Target information

    Target ID GM-T58454
    Target Name FGFR2
    Gene ID 2263, 14183, 715949, 25022, 101095198, 415125, 404193, 100033956
    Gene Symbol and Synonyms BBDS,BEK,BFR-1,CD332,CEK3,CFD1,ECT1,FGFR,Fgfr-2,Fgfr-7,FGFR2,Fgfr2b,fgfr2IIIb,FGFR2IIIC,Fgfr7,JWS,K-SAM,KGFR,KGFRTr,svs,TK14,TK25
    Uniprot Accession P21802
    Uniprot Entry Name FGFR2_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, INN Index, Cytokine Target
    Disease Non-Small Cell Lung Cancer
    Gene Ensembl ENSG00000066468
    Target Classification Kinase

    The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]



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