Human CTSB/APPS/CPSB ORF/cDNA clone-Lentivirus plasmid (NM_001908.4)

Cat. No.: pGMLV000311
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human CTSB/APPS/CPSB Lentiviral expression plasmid for CTSB lentivirus packaging, CTSB lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product Description

Catalog ID pGMLV000311
Gene Name CTSB
Accession Number NM_001908.4
Gene ID 1508
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 1020 bp
Gene Alias APPS,CPSB
Fluorescent Reporter Null
Mammalian Cell Selection Blasticidin (BSD)
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T61746-Ab Anti-CATB/ CTSB/ APPS functional antibody
    Target Antigen GM-Tg-g-T61746-Ag CTSB protein
    ORF Viral Vector pGMLV000311 Human CTSB Lentivirus plasmid
    ORF Viral Vector vGMLV000311 Human CTSB Lentivirus particle


    Target information

    Target ID GM-T61746
    Target Name CTSB
    Gene ID 1508, 13030, 100424758, 64529, 101084873, 486077, 281105, 100060963
    Gene Symbol and Synonyms APPS,CATB,CB,CPSB,CTSB,KWE,RECEUP
    Uniprot Accession P07858
    Uniprot Entry Name CATB_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease Malignant neoplasm of bladder, IgA glomerulonephritis, tumors
    Gene Ensembl ENSG00000164733
    Target Classification Not Available

    This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020]



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