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Human TNFRSF10B/CD262/DR5 ORF/cDNA clone-Lentivirus plasmid (NM_003842.4)
Cat. No.: pGMLV000251
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days
Pre-made Human TNFRSF10B/CD262/DR5 Lentiviral expression plasmid for TNFRSF10B lentivirus packaging, TNFRSF10B lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.
Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.
Datasheet
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Product Description
| Catalog ID | pGMLV000251 |
| Gene Name | TNFRSF10B |
| Accession Number | NM_003842.4 |
| Gene ID | 8795 |
| Species | Human |
| Product Type | Lentivirus plasmid (overexpression) |
| Insert Length | 1323 bp |
| Gene Alias | CD262,DR5,KILLER,KILLER/DR5,TRAIL-R2,TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,ZTNFR9 |
| Fluorescent Reporter | Firefly luciferase |
| Mammalian Cell Selection | Puromyocin |
| Fusion Tag | Null |
| Promoter | CMV |
| Resistance | Amplicin |
Reference
Data / case study
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Associated products
Target information
| Target ID | GM-T70067 |
| Target Name | TRAIL-R2 |
| Gene ID | 8795, 21933, 716650, 100057812 |
| Gene Symbol and Synonyms | CD262,DR5,KILLER,KILLER/DR5,Ly98,MK,TNFRSF10B,TRAIL-R2,TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,ZTNFR9 |
| Uniprot Accession | O14763 |
| Uniprot Entry Name | TR10B_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000120889 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
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