Human GJB2/CX26/HID ORF/cDNA clone-Adenovirus plasmid (BC017048)

Cat. No.: pGMAP000519
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human GJB2/CX26/HID adenoviral expression plasmid for GJB2 adenovirus packaging, GJB2 adenovirus.

Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.

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Product Description

Catalog ID pGMAP000519
Gene Name GJB2
Accession Number BC017048
Gene ID 2706
Species Human
Product Type Adenovirus plasmid (overexpression)
Insert Length 681 bp
Gene Alias CX26,HID,KID,NSRD1,PPK
Fluorescent Reporter GFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin
ORF Nucleotide Sequence ATGGATTGGGGCACGCTGCAGACGATCCTGGGGGGTGTGAACAAACACTCCACCAGCATTGGAAAGATCTGGCTCACCGTCCTCTTCATTTTTCGCATTATGATCCTCGTTGTGGCTGCAAAGGAGGTGTGGGGAGATGAGCAGGCCGACTTTGTCTGCAACACCCTGCAGCCAGGCTGCAAGAACGTGTGCTACGATCACTACTTCCCCATCTCCCACATCCGGCTATGGGCCCTGCAGCTGATCTTCGTGTCCACGCCAGCGCTCCTAGTGGCCATGCACGTGGCCTACCGGAGACATGAGAAGAAGAGGAAGTTCATCAAGGGGGAGATAAAGAGTGAATTTAAGGACATCGAGGAGATCAAAACCCAGAAGGTCCGCATCGAAGGCTCCCTGTGGTGGACCTACACAAGCAGCATCTTCTTCCGGGTCATCTTCGAAGCCGCCTTCATGTACGTCTTCTATGTCATGTACGACGGCTTCTCCATGCAGCGGCTGGTGAAGTGCAACGCCTGGCCTTGTCCCAACACTGTGGACTGCTTTGTGTCCCGGCCCACGGAGAAGACTGTCTTCACAGTGTTCATGATTGCAGTGTCTGGAATTTGCATCCTGCTGAATGTCACTGAATTGTGTTATTTGCTAATTAGATATTGTTCTGGGAAGTCAAAAAAGCCAGTTTAA
ORF Protein Sequence MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T88947-Ab Anti-CXB2/ Cx26/ GJB2 monoclonal antibody
    Target Antigen GM-Tg-g-T88947-Ag Cx26/GJB2 VLP (virus-like particle)
    ORF Viral Vector pGMAP000033 Human GJB2 Adenovirus plasmid
    ORF Viral Vector pGMAP000519 Human GJB2 Adenovirus plasmid
    ORF Viral Vector vGMAP000033 Human GJB2 Adenovirus particle
    ORF Viral Vector vGMAP000519 Human GJB2 Adenovirus particle


    Target information

    Target ID GM-T88947
    Target Name Cx26
    Gene ID 2706, 14619, 704224, 394266, 101082540, 403570, 407154, 100050084
    Gene Symbol and Synonyms BAPS,Cnx26,CX26,CXN-26,Cxne,DFNA3,DFNA3A,DFNB1,DFNB1A,Gjb-2,GJB2,HID,KID,NSRD1,PPK
    Uniprot Accession P29033
    Uniprot Entry Name CXB2_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000165474
    Target Classification Tumor-associated antigen (TAA)

    This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]



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