Human IL24/C49A/FISP ORF/cDNA clone-Adenovirus plasmid (NM_006850)

Cat. No.: pGMAP-IL-114
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human IL24/C49A/FISP adenoviral expression plasmid for IL24 adenovirus packaging, IL24 adenovirus.

Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.

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Product Description

Catalog ID pGMAP-IL-114
Gene Name IL24
Accession Number NM_006850
Gene ID 11009
Species Human
Product Type Adenovirus plasmid (overexpression)
Insert Length 621 bp
Gene Alias C49A,FISP,IL10B,MDA7,MOB5,ST16
Fluorescent Reporter EGFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Kanamycin
ORF Nucleotide Sequence ATGAATTTTCAACAGAGGCTGCAAAGCCTGTGGACTTTAGCCAGACCCTTCTGCCCTCCTTTGCTGGCGACAGCCTCTCAAATGCAGATGGTTGTGCTCCCTTGCCTGGGTTTTACCCTGCTTCTCTGGAGCCAGGTATCAGGGGCCCAGGGCCAAGAATTCCACTTTGGGCCCTGCCAAGTGAAGGGGGTTGTTCCCCAGAAACTGTGGGAAGCCTTCTGGGCTGTGAAAGACACTATGCAAGCTCAGGATAACATCACGAGTGCCCGGCTGCTGCAGCAGGAGGTTCTGCAGAACGTCTCGGATGCTGAGAGCTGTTACCTTGTCCACACCCTGCTGGAGTTCTACTTGAAAACTGTTTTCAAAAACTACCACAATAGAACAGTTGAAGTCAGGACTCTGAAGTCATTCTCTACTCTGGCCAACAACTTTGTTCTCATCGTGTCACAACTGCAACCCAGTCAAGAAAATGAGATGTTTTCCATCAGAGACAGTGCACACAGGCGGTTTCTGCTATTCCGGAGAGCATTCAAACAGTTGGACGTAGAAGCAGCTCTGACCAAAGCCCTTGGGGAAGTGGACATTCTTCTGACCTGGATGCAGAAATTCTACAAGCTCTGA
ORF Protein Sequence MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T93450-Ab Anti-IL24/ C49A/ FISP functional antibody
    Target Antigen GM-Tg-g-T93450-Ag IL24 protein
    Cytokine cks-Tg-g-GM-T93450 interleukin 24 (IL24) protein & antibody
    ORF Viral Vector pGMLV000181 Human IL24 Lentivirus plasmid
    ORF Viral Vector pGMAD000195 Human IL24 Adenovirus plasmid
    ORF Viral Vector pGMLP-IL-031 Human IL24 Lentivirus plasmid
    ORF Viral Vector pGMAP-IL-114 Human IL24 Adenovirus plasmid
    ORF Viral Vector vGMLV000181 Human IL24 Lentivirus particle
    ORF Viral Vector vGMAD000195 Human IL24 Adenovirus particle
    ORF Viral Vector vGMLP-IL-031 Human IL24 Lentivirus particle
    ORF Viral Vector vGMAP-IL-114 Human IL24 Adenovirus particle


    Target information

    Target ID GM-T93450
    Target Name IL24
    Gene ID 11009, 93672, 694541, 170819, 101095874, 609213, 526285, 100055675
    Gene Symbol and Synonyms C49A,FISP,If2e,IL10B,IL24,Mda-7,MDA7,MOB5,ST16
    Uniprot Accession Q13007
    Uniprot Entry Name IL24_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target, Cytokine Target
    Disease Cancer
    Gene Ensembl ENSG00000162892
    Target Classification Tumor-associated antigen (TAA)

    This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]



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