Human LDLR/FH/FHC ORF/cDNA clone-Adenovirus plasmid (NM_000527.5)

SKU: pGMAD001086
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human LDLR/FH/FHC adenoviral expression plasmid for LDLR adenovirus packaging, LDLR adenovirus.

Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.

pdf MSDS
pdf Datasheet
pdf Terms of Use
Target products collection

Go to LDL-R/LDLR/FH products collection>>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Purchase
Shipping fee: Limited-time free


Product Description

Catalog ID pGMAD001086
Gene Name LDLR
Accession Number NM_000527.5
Gene ID 3949
Species Human
Product Type Adenovirus plasmid (overexpression)
Insert Length 2583 bp
Gene Alias FH,FHC,FHCL1,LDLCQ2
Fluorescent Reporter Null
Mammalian Cell Selection Null
Fusion Tag 6xHis (C-Terminal)
Promoter CMV
Resistance Kanamycin

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T94692-Ab Anti-LDLR/ LDL-R/ FH monoclonal antibody
    Target Antigen GM-Tg-g-T94692-Ag LDL-R/LDLR VLP (virus-like particle)
    ORF Viral Vector pGMLP005154 Human LDLR Lentivirus plasmid
    ORF Viral Vector pGMAD001086 Human LDLR Adenovirus plasmid
    ORF Viral Vector pGMPC001457 Human LDLR Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP005154 Human LDLR Lentivirus particle
    ORF Viral Vector vGMAD001086 Human LDLR Adenovirus particle


    Target information

    Target ID GM-T94692
    Target Name LDL-R
    Gene ID 3949, 16835, 574283, 300438, 101080362, 100683160, 281276, 100057389
    Gene Symbol and Synonyms FH,FHC,FHCL1,Hlb301,LDLCQ2,LDLR,LDLRA
    Uniprot Accession P01130
    Uniprot Entry Name LDLR_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000130164
    Target Classification Tumor-associated antigen (TAA)

    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]



    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.