Human ACVR1/ACTRI/ACVR1A ORF/cDNA clone-Adenovirus plasmid (NM_001111067.2)

Cat. No.: pGMAD000055
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human ACVR1/ACTRI/ACVR1A adenoviral expression plasmid for ACVR1 adenovirus packaging, ACVR1 adenovirus.

Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.

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Product Description

Catalog ID pGMAD000055
Gene Name ACVR1
Accession Number NM_001111067.2
Gene ID 90
Species Human
Product Type Adenovirus plasmid (overexpression)
Insert Length 1530 bp
Gene Alias ACTRI,ACVR1A,ACVRLK2,ALK2,FOP,SKR1,TSRI
Fluorescent Reporter GFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T12091-Ab Anti-ACVR1/ ALK-2/ ACTRIA monoclonal antibody
    Target Antigen GM-Tg-g-T12091-Ag ALK-2/ACVR1 VLP (virus-like particle)
    Cytokine cks-Tg-g-GM-T12091 activin A receptor, type I (ACVR1) protein & antibody
    ORF Viral Vector pGMLP005182 Human ACVR1 Lentivirus plasmid
    ORF Viral Vector pGMAD000055 Human ACVR1 Adenovirus plasmid
    ORF Viral Vector vGMLP005182 Human ACVR1 Lentivirus particle
    ORF Viral Vector vGMAD000055 Human ACVR1 Adenovirus particle


    Target information

    Target ID GM-T12091
    Target Name ALK-2
    Gene ID 90, 11477, 697935, 79558, 101091298, 478757, 338068, 100050899
    Gene Symbol and Synonyms ActR-I,ActR-IA,ACTRI,ActRIA,Acvr,ACVR1,ACVR1A,ACVRLK2,Alk-2,ALK2,Alk8,D330013D15Rik,FOP,SKR1,Tsk7L,TSRI
    Uniprot Accession Q04771
    Uniprot Entry Name ACVR1_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Cytokine Target
    Disease Not Available
    Gene Ensembl ENSG00000115170
    Target Classification Kinase

    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]



    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.