Human AXL/ARK/AXL3 ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_021913)

Cat. No.: pGMAAV001760
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human AXL/ARK/AXL3 Adeno-associated virus expression plasmid (ITR-vector) for AXL AAV packaging, AXL AAV production.The purified Human AXL/ARK/AXL3 AAV particle serves as an invaluable asset for in-depth in vivo AXL studies, mechanism of action (MOA) research, and the evolution of AXL-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

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Product Description

Catalog ID pGMAAV001760
Gene Name AXL
Accession Number NM_021913
Gene ID 558
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 2685 bp
Gene Alias ARK,AXL3,JTK11,Tyro7,UFO
Fluorescent Reporter Null
Mammalian Cell Selection Null
Fusion Tag 6xHis (C-Terminal)
Promoter POSTN
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Biosimilar GMP-Bios-ab-575 Pre-Made Tilvestamab biosimilar, Whole mAb, Anti-AXL Antibody: Anti-ARK/UFO/JTK11/Tyro7 therapeutic antibody
    Biosimilar GMP-Bios-ab-179 Pre-Made Enapotamab biosimilar, Whole mAb ADC, Anti-AXL Antibody: Anti-ARK/UFO/JTK11/Tyro7 therapeutic antibody
    Biosimilar GMP-Bios-INN-832 Pre-Made Enapotamab Vedotin Biosimilar, Whole Mab Adc, Anti-Axl Antibody: Anti-ARK/JTK11/Tyro7/UFO therapeutic antibody Drug Conjugate
    Biosimilar GMP-Bios-ab-345 Pre-Made Mipasetamab biosimilar, Whole mAb, Anti-AXL Antibody: Anti-ARK/UFO/JTK11/Tyro7 therapeutic antibody
    Biosimilar GMP-Bios-INN-910 Pre-Made Mipasetamab Uzoptirine Biosimilar, Whole Mab Adc, Anti-Axl Antibody: Anti-ARK/JTK11/Tyro7/UFO therapeutic antibody Drug Conjugate
    Target Antibody GM-Tg-g-T82383-Ab Anti-UFO/ AXL/ ARK monoclonal antibody
    Target Antigen GM-Tg-g-T82383-Ag AXL VLP (virus-like particle)
    ORF Viral Vector pGMLP001812 Human AXL Lentivirus plasmid
    ORF Viral Vector pGMLP005364 Human AXL Lentivirus plasmid
    ORF Viral Vector pGMLV002669 Human AXL Lentivirus plasmid
    ORF Viral Vector pGMAD000544 Human AXL Adenovirus plasmid
    ORF Viral Vector pGMAAV001760 Human AXL Adeno-associate virus(AAV) plasmid
    ORF Viral Vector vGMLP001812 Human AXL Lentivirus particle
    ORF Viral Vector vGMLP005364 Human AXL Lentivirus particle
    ORF Viral Vector vGMLV002669 Human AXL Lentivirus particle
    ORF Viral Vector vGMAD000544 Human AXL Adenovirus particle
    ORF Viral Vector vGMAAV001760 Human AXL Adeno-associate virus(AAV) particle


    Target information

    Target ID GM-T82383
    Target Name AXL
    Gene ID 558, 26362, 706123, 308444, 101086688, 484490, 516598, 100064907
    Gene Symbol and Synonyms ARK,AXL,JTK11,Tyro7,UFO
    Uniprot Accession P30530
    Uniprot Entry Name UFO_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Immuno-oncology Target, INN Index
    Disease Cancer
    Gene Ensembl ENSG00000167601
    Target Classification Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]



    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.