Human IL37/FIL1/FIL1(ZETA) ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_014439)

SKU: pGMAAV000475
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human IL37/FIL1/FIL1(ZETA) Adeno-associated virus expression plasmid (ITR-vector) for IL37 AAV packaging, IL37 AAV production.The purified Human IL37/FIL1/FIL1(ZETA) AAV particle serves as an invaluable asset for in-depth in vivo IL37 studies, mechanism of action (MOA) research, and the evolution of IL37-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

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Product Description

Catalog ID pGMAAV000475
Gene Name IL37
Accession Number NM_014439
Gene ID 27178
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 657 bp
Gene Alias FIL1,FIL1(ZETA),FIL1Z,IL-1F7,IL-1H,IL-1H4,IL-1RP1,IL-37,IL1F7,IL1H4,IL1RP1
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T96845-Ab Anti-IL37/ FIL1/ FIL1(ZETA) functional antibody
    Target Antigen GM-Tg-g-T96845-Ag IL37 protein
    Cytokine cks-Tg-g-GM-T96845 interleukin 37 (IL37) protein & antibody
    ORF Viral Vector pGMLV000120 Human IL37 Lentivirus plasmid
    ORF Viral Vector pGMAAV000475 Human IL37 Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMAP000269 Human IL1F7 Adenovirus plasmid
    ORF Viral Vector pGMLP-IL-043 Human IL37 Lentivirus plasmid
    ORF Viral Vector pGMAP-IL-126 Human IL37 Adenovirus plasmid
    ORF Viral Vector vGMLV000120 Human IL37 Lentivirus particle
    ORF Viral Vector vGMAAV000475 Human IL37 Adeno-associate virus(AAV) particle
    ORF Viral Vector vGMAP000269 Human IL1F7 Adenovirus particle
    ORF Viral Vector vGMLP-IL-043 Human IL37 Lentivirus particle
    ORF Viral Vector vGMAP-IL-126 Human IL37 Adenovirus particle


    Target information

    Target ID GM-T96845
    Target Name IL37
    Gene ID 27178, 700579, 100686057, 786493, 100052470
    Gene Symbol and Synonyms FIL1,FIL1(ZETA),FIL1Z,IL-1F7,IL-1H,IL-1H4,IL-1RP1,IL-23,IL-37,IL1F7,IL1H4,IL1RP1,IL37
    Uniprot Accession Q9NZH6
    Uniprot Entry Name IL37_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target, Cytokine Target
    Disease Not Available
    Gene Ensembl ENSG00000125571
    Target Classification Not Available

    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]



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