GeneMedi's Pathway Assays portfolio for drug discovery and mechanism of action (MOA) research.

GeneMedi’s Pathway portfolio includes a selection of kits that help to map intracellular and extracellular signaling pathways. They are series of molecular interactions that control cellular processes and have been implicated in the processes of disease initiation and progression. These pathways have been implicated in the control of numerous cellular processes such as cell signaling, metabolism and gene expression. The discovery of particular pathways and the signaling molecules connected to them has now made it possible to identify particular applications for diagnosis and treatment. For instance, pathways are implicated in the development of various diseases such as cancer, neurodegenerative diseases, metabolic diseases among others and are as such potential therapeutic targets.

There are some classifications of the pathways according to their structural and functional characteristics. Different classification of pathways have been described and one of the most common is based on the location of the pathway, whether it is intracellular or extracellular. Every category of the pathway includes a number of significant proteins which have different functions and uses in therapeutics. For instance, intracellular pathways are the MAPK pathway, PI3K pathway and the Wnt/beta-catenin pathway which are involved in cell signaling, regulation of cell cycle plus immune responses. Extracellular pathways are the cytokine signaling pathway, TGF-beta signaling pathway and FGF signaling pathway through which cell proliferation, differentiation and survival is controlled. Further, the over or under expression of certain pathways has been seen as a cause of or as a predictor of disease and their identification can help in diagnosis and prediction of the disease course.

GeneMedi also offers investigators research antibodies, including the standard monoclonal antibodies (mAbs) produced in mammalian systems. These products have high sensitivity and specificity, and can be used for cell culture, assay development, animal model development, PK/PD model development and MOA research in biological drug discovery as reference therapeutic antibodies. All in all, pathways are a heterogeneous and promising type of targets, which offer a wide range of possibilities for the drug discovery. Such pathways are essential in both the diagnostics and therapeutics because the multiple and intricate pathways and their functions make them ideal targets for diagnosis and treatment, including classification of the pathways that can be exploited for precision medicine and tailored treatments.

Q&A

Q1. What are pathways?
A1: Pathways are a sequence of molecular connections that help in controlling cellular activities and are implicated in the advancement and modulation of diseases.

Q2. What role do pathways play in drug discovery?
A2: Pathways are a focus of drug discovery in the pharmaceutical industry because they are involved in controlling numerous cellular processes such as signaling and metabolism which are involved in the appearance and advancement of diseases.

Q3. What are the two main types of pathways, through which can be divided all the cell signaling?
A3: There are two major groups of pathways: intracellular and extracellular, and these pathways involve several proteins of significance for their functions and use in therapeutics.

Q4. What are benchmark antibodies?
A4: Benchmark antibodies are also known as reference therapeutic antibodies and are employed in the drug development process as well as in other research processes such as in the development of an assay, animal models, and in understanding the mechanism of action.

Q5. Which diseases are associated with pathways?
A5: Dysregulation of certain pathways has turned out to be crucial in the growth and advancement of diseases such as malignancy, neurodegenerative disorders, metabolic ailments, and others.