GeneMedi's Kinase portfolio for drug discovery and mechanism of action (MOA) research.

GeneMedi’s Kinase product line is a collection of assay kits, inhibitors, and activators intended for the study of kinase pathways in disease models. Protein kinase are a group of enzymes that are involved in transferring phosphate groups from adenosine triphosphate (ATP) molecules to proteins so as to control their activity. It is involved in the control of numerous cellular functions, among which are signaling, metabolism and transcription and translation. Protein kinases are of great interest to the pharmaceutical industry because they are related to the development of many diseases such as cancer, neurodegenerative diseases, and metabolic disorders. Protein kinases can be categorised depending on the characteristics of the enzyme, including serine/threonine kinases as well as tyrosine kinases.

The serine/threonine kinases, PKA, PKC and MAPK for instance, are involved in cell signaling, cell cycle regulation and the immune response. On the other hand, tyrosine kinases of which the categories include receptor tyrosine kinases, non-receptor tyrosine kinases, and tyrosine kinase associated receptors are involved in the regulation of cell growth, differentiation and survival. This has been so because with the identification and targeting of certain protein kinases and their associated pathways, there has been formation of some diagnostic and therapeutic practices. Protein kinases can be also employed as diagnostic biomarkers because the overexpression or mutation of some specific kinases is associated with cancer development and progression and can be applied to early diagnosis and prognosis. Some of the drugs include the kinase inhibitors that are proteins kinase substrates that have been used in the treatment of different diseases.

In conclusion, protein kinases are diverse and promising group of targets in drug discovery and development. Due to the intricate signaling pathways and roles they play in various diseases, they are used in both diagnostic and therapeutic purposes; the classification and identification of these proteins provide a chance for precision medicine and individualized treatments. These include: ELISA, affinity binding assays, drug discovery and mechanism of action (MOA) research, for which GeneMedi offers benchmark antibodies in relation to Kinase. All our pre-made monoclonal antibodies (mAbs) are produced from mammalian expression systems to assure the best performance of the products. These mAbs can be used as positive control for cell culture, assay development, animal model development, PK/PD model development (pharmacokinetics & pharmacodynamics) and MOA research for drug discovery of biologic.

Q&A

Q1. What is included in GeneMedi’s Kinase portfolio?
A1: The GeneMedi’s Kinase portfolio contain assay kits and inhibitors and activators that enable researchers to study kinase signaling pathways in diseases.

Q2. What are protein kinases?
A2: Protein kinases are a class of enzymes that modulate protein activity and function through the addition of phosphate groups from ATP molecules.

Q3. What are some of the biological processes that protein kinases regulate?
A3: Protein kinases are involved in the control of a number of cellular activities such as signal transduction, metabolism and gene expression.

Q4. What makes protein kinases such valuable target for drug discovery?
A4 Protein kinases are involved in the pathogenesis of various diseases, including malignancies, neurodegenerative disorders, and metabolic diseases and are, therefore, potential drug targets.

Q5. What types of monoclonal antibodies does GeneMedi offer for Kinase research?
A5: GeneMedi offers pre-made monoclonal antibodies (mAbs) expressed using mammalian cell lines: these can be used as reference therapeutic antibodies in cell culture, assay development, animal model development, PK/PD model development and MOA research for biological drug discovery.