GeneMedi's Epigenetic portfolio for drug discovery and mechanism of action (MOA) research.

GeneMedi has a full Epigenetic line of products that contains advanced solutions for studying the epigenetic changes that control gene activity. Epigenetics is a relatively young and fast-growing branch of biology that researches the modifications of phenotype that is, a state of a cell or an organism at a particular moment in time that can be passed to the next generation without changing the DNA sequence. Because epigenetic mechanisms are useful for diagnostics and therapeutics, this area is of great interest to the biopharmaceutical industry. Epigenetic modifications can be categorised into several types based on the proteins they affect in gene regulation; these include DNA methylation, histone modification, and non-coding RNA regulation.

DNA methylation is a biochemical modification of DNA molecule in which methyl group is inserted. This classification aims at DNA methyltransferase enzymes that are involved in the process of transferring methyl groups to DNA thus affecting gene expression. DNA methylation is used in cancer diagnosis, it is useful in the monitoring of the progression of the disease and the effectiveness of the treatment. Another classification of the epigenetic modifications is the histone modification which refer to the addition or removal of chemical groups to the histone proteins that are part of the nucleosome, a basic unit of the chromatin fiber. This modification affect enzymes like histone acetyltransferases and histone deacetylases which are involved in gene expression. Histone modification has been used in different diseases such as cancer, neurological diseases, and autoimmune diseases. Non-coding RNA regulation is one of the most intricate and dynamically developing facets of epigenetics that aims at the regulation of different kinds of non-coding RNA molecules which are involved in gene regulation and include microRNAs and long non-coding RNAs. Non-coding RNA regulation has been important in disease detection and management with possibilities of application in cancer immunotherapy, neurodegenerative disease management and regenerative medicine.

In sum, the field of epigenetics is interesting and ongoing with a lot of prospects for the future diagnostics and treatments. Because epigenetic therapies are capable of modulating proteins related to gene expression, they can be used to develop individualised and efficient treatments for various diseases. GeneMedi offers control antibodies for many experimental uses in epigenetics field such as ELISA, affinity binding assays, drug development and MOA research. All of our premade monoclonal antibodies are derived from mammalian cell lines to guarantee the highest quality and reliability of the product. It can be used in cell culture, assay development, animal model development, PK/PD model development (pharmacokinetics & pharmacodynamic), and MOA research for biological drug discovery as reference therapeutic antibody.

Q&A

Q1. What is epigenetics?
Epigenetics is a branch of biology which deals with changes in the phenotype which are heritable but not based on changes in the DNA code.

Q2. Some of the examples of the epigenetic modification are?
There are different categories of epigenetic modifications, among which are DNA methylation, histone modifications, and regulation of non-coding RNA.

Q3. In what ways could epigenetic mechanisms be employed in the diagnosis and treatment?
A3: Epigenetic targets are particularly attractive for diagnostics and therapeutics and are therefore of high interest for the biopharmaceutical industry.

Q4. What is DNA methylation?
A4: DNA methylation is a biological process that entail the addition of methyl group onto the DNA molecule which alters gene activity.

Q5. In which types of diseases is histone modification useful?
A5 Histone modification has potential for use in numerous diseases, including malignant tumors, neurodegenerative diseases, and autoimmune diseases.