Immuno-Diagnostics Antibodies & Antigens for Veterinary Inflammation Test
Immuno-diagnostic antibodies and antigens for inflammation diagnosis in animals target specific markers like
CRP, SAA, and procalcitonin. These components are essential for developing assays that accurately detect and
quantify inflammatory responses, aiding in the early diagnosis and management of inflammatory diseases in
veterinary medicine, ensuring timely and effective treatment.
| Catalog No. | Products Name | Specific Host | Products Information |
| GMP-BOV-Serum-amyloid-A-Ag | Bovine Serum amyloid A | Bovines/Cattle | Details |
| GMP-BOV-Serum-amyloid-A-Ab | Anti-bovine SAA protein monoclonal antibody (mAb) | Bovines/Cattle | Details |
| GMP-CAN-Serum-amyloid-A-Ab | Anti-Canine Serum amyloid A monoclonal antibody (mAb) | Dog/Canine | Details |
| GMP-CAN-Serum-amyloid-A-Ag | Serum amyloid A | Dog/Canine | Details |
| GMP-EQU-Serum-amyloid-A-Ab | Anti-Equine SAA monoclonal antibody (mAb) | Equine/Horse | Details |
| GMP-EQU-Serum-amyloid-A-Ag | Serum amyloid A | Equine/Horse | Details |
| GMP-FEL-Serum-amyloid-A-Ab | Anti-Feline Serum amyloid A monoclonal antibody (mAb) | Cat/Feline | Details |
| GMP-FEL-Serum-amyloid-A-Ag | Serum amyloid A | Cat/Feline | Details |
| GMP-CAN-PCT-Ag | PCT | Dog/Canine | Details |
| GMP-CAN-PCT-Ab | Anti-Canine PCT monoclonal antibody (mAb) | Dog/Canine | Details |
| GMP-EQU-PCT-Ag | PCT | Equine/Horse | Details |
| GMP-EQU-PCT-Ab | Anti-Equine PCT monoclonal antibody (mAb) | Equine/Horse | Details |
| GMP-FEL-PCT-Ag | PCT | Cat/Feline | Details |
| GMP-FEL-PCT-Ab | Anti-Feline PCT monoclonal antibody (mAb) | Cat/Feline | Details |
| GMP-BOV-CRP-Ag | C-Reactive Protein | Bovines/Cattle | Details |
| GMP-BOV-CRP-Ab | Anti-Bovine CRP monoclonal antibody (mAb) | Bovines/Cattle | Details |
| GMP-CAN-CRP-Ag | C-Reactive Protein | Dog/Canine | Details |
| GMP-CAN-CRP-Ab | Anti-Canine C-Reactive Protein (CRP) monoclonal antibody (mAb) | Dog/Canine | Details |
| GMP-EQU-CRP-Ag | C-Reactive Protein | Equine/Horse | Details |
| GMP-EQU-CRP-Ab | Anti-Equine CRP monoclonal antibody (mAb) | Equine/Horse | Details |
| GMP-FEL-CRP-Ag | C-Reactive Protein | Cat/Feline | Details |
| GMP-FEL-CRP-Ab | Anti-Feline CRP monoclonal antibody (mAb) | Cat/Feline | Details |
What is Inflammation and how does it Manifest in Different Animals?
Inflammation is a fundamental physiological response to injury, infection, or irritation in animals, just as it is in humans. It serves as the body's mechanism to initiate the healing process, involving the immune system fighting off invading pathogens, repairing damaged tissues, and restoring normal function. The signs of inflammation can be characterized by five classic symptoms: pain, heat, redness, swelling, and loss of function at the affected site.
Animals Affected by Inflammation
Virtually all animals with an immune system can experience inflammation. This includes a wide range of animals, from domestic pets to wildlife:
Domestic Pets:
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· Dogs and Cats: Commonly suffer from inflammation due to various causes, including infections, allergies, chronic diseases (such as arthritis), and injuries.
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· Small Mammals: Rabbits, guinea pigs, and ferrets can also experience inflammation, often evidenced by skin conditions, digestive issues, or respiratory problems.
Livestock:
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· Cattle, Sheep, and Goats: These animals can develop inflammatory conditions like mastitis (inflammation of the mammary gland), foot rot, or systemic infections.
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· Horses: Prone to inflammation in the form of laminitis (inflammation of the tissues within the hoof), tendonitis, and colitis, among other conditions.
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· Wildlife: Wild animals are equally susceptible to inflammation, which can be more difficult to diagnose and treat. Inflammation can arise from natural causes, such as predation injuries or infections, or from human-induced factors, like pollution or habitat destruction.
The Top 10 Inflammatory Biomarkers: Roles and Importance
This table outlines critical biomarkers like SAA, CRP, and NT-proBNP, their normal ranges, and implications in diseases for dogs and cats. It serves as a reference for veterinarians to assess inflammation, infection, and cardiac health, incorporating measurement methods and age considerations.
| Biomarker | Normal Range (Dogs) | Normal Range (Cats) | Implications in Disease | Specimens/Biofluids | Age Considerations | Measurement Method |
|---|---|---|---|---|---|---|
| SAA (Serum Amyloid A) | <100 µg/mL | <10 µg/mL | Acute inflammation, infection | Blood, Serum | Levels may increase with age | Immunoassay |
| CRP (C-Reactive Protein) | <10 mg/L | <10 mg/L | Inflammation, infection | Blood, Serum | Elderly pets may have higher baseline levels | Immunoassay |
| PCT (Procalcitonin) | Not commonly measured | Not commonly measured | Bacterial infection (less used in veterinary medicine) | Blood, Serum | Not well-established in pets | Immunoassay |
| NT-proBNP | <900 pg/mL | <100 pg/mL | Heart disease | Blood, Plasma | Increases with cardiac stress and age | Immunoassay |
| D-Dimer | 0-0.5 µg/mL | 0-0.5 µg/mL | Thrombosis, DIC | Blood, Plasma | No specific age correlation | Immunoassay |
| cTnI (Cardiac Troponin I) | <0.1 ng/mL | <0.1 ng/mL | Cardiac injury | Blood, Serum | Not significantly affected by age | Immunoassay |
| Albumin | 2.5-4.0 g/dL | 2.5-3.9 g/dL | Liver disease, chronic inflammation | Blood, Serum | Decreases in chronic disease | Biochemical assay |
| ALT (Alanine Aminotransferase) | 10-125 U/L | 10-100 U/L | Liver injury | Blood, Serum | Younger animals may have slightly higher levels due to growth | Biochemical assay |
| Creatinine | 0.6-1.2 mg/dL | 0.6-2.4 mg/dL | Kidney function | Blood, Serum | Older pets may have higher levels due to decreased kidney function | Biochemical assay |
| Glucose | 70-150 mg/dL | 70-150 mg/dL | Diabetes, stress response | Blood, Serum | Puppies/kittens may have lower baseline levels; stress can elevate | Biochemical assay |
Diagnosing and Treating Inflammation in Animals
Inflammation is diagnosed based on clinical signs, medical history, and diagnostic tests, including blood tests to identify markers of inflammation (e.g., C-reactive protein) and imaging studies to assess the affected areas. Treatment varies with the underlying cause but generally involves:
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Anti-inflammatory Medications: Nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to reduce inflammation and pain.
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Antibiotics or Antifungal Medications: If the inflammation is due to an infection.
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Dietary Management and Supplements: Especially for chronic inflammatory conditions like arthritis, where omega-3 fatty acids may help reduce inflammation.
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Surgery: In cases where physical removal of the cause of inflammation is necessary (e.g., abscess drainage, tumor removal).
Preventive care, including regular veterinary check-ups, vaccinations, and maintaining a healthy lifestyle, can help minimize the risk of inflammatory diseases in animals. Early detection and treatment are key to effectively managing inflammation and preventing its progression into more serious conditions.
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