Creatinine Antibodies & Antigens for Kidney Function Test

Creatinine clearance is one of the most essential investigations that are used to determine the status of the kidney. It assesses the quantity of creatinine in the blood streaming through the kidneys with regards to the cleanup of squanders.

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Product list of GeneMedi's Creatinine Products

Cat No.	Product Description	Product Type	Products Information
GMP-SMT-cr-Ab	Anti-creatinine (cr) antibody	antibody(Fc/mFc)	Details
GMP-SMT-cr-Ag	creatinine (cr) antigen	chemicals-BSA/OVA	Details

• Introduction
• Application
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What is Creatinine test for Assessing Kidney Function?

Creatinine clearance test is important in checking the kidney function, since it estimate the amount of creatinine in the blood stream. Creatinine as a metabolic product of muscles should be effectively removed by the kidneys of a healthy person. Creatinine is a byproduct of creatine, which is a component of muscle tissue, and the levels of creatinine rise in cases of renal impairment or kidney diseases; therefore, creatinine levels form the basis of the assessment of renal health. It is a blood test that can aid sites across the healthcare niche in determining the glomerular filtration rate or GFR all in a bid to evaluate kidney health. Correct being monitored through creatinine tests is useful to those people who suffer from hypertension, diabetes or cardiovascular diseases, and other equivalent episodes that impact the kidneys and also those people who undergo through some medical procedures that have an effect on the renal system.

Why use Creatinine as a biomarker?

Creatinine is a reliable marker of kidney function because its blood level reflects kidney filtering performance.

Biomarkers for Kidney Function Assessment Across Different Species

Species	Normal Range	Possible Diseases Listed	Specimens/Biofluids	Measurement Method
Human	0.6-1.2 mg/dL	Chronic kidney disease, Acute renal failure	Blood, Urine	Jaffe method, Enzymatic assay
Cat	0.6-2.4 mg/dL	Kidney disease, Urethral obstruction	Blood, Urine	Jaffe method
Dog	0.5-1.8 mg/dL	Kidney dysfunction, Renal failure	Blood, Urine	Jaffe method
Horse	1.2-2.0 mg/dL	Kidney damage, Dehydration	Blood	Enzymatic assay
Cattle	0.9-2.1 mg/dL	Renal impairment, Toxicity	Blood	Enzymatic assay

This table also shows that there is a need for creatinine in determining the health of the kidneys across the species. It also covers the normal values in various species, diseases that affect creatinine concentration and the techniques in estimating it. The differences in normal ranges depend on species’ metabolic rates and body weight, which are essential for the correct interpretation of the test results. But firstly, it is useful to sum up the use of creatinine as a marker of the kidney function and the importance of distinguishing species and clinical cases specifics.

Why Use Creatinine Pair Antibody and Antigen in Kidney Function Immuno-diagnostics?

1. Specificity: This indicates that creatinine antibody-antigen binding is quite specific hence minimizing the chances of cross-reactions and hence high chances of getting a wrong positive result.

2. Sensitivity: Great news for those that require creatinine detection, immunoassays can be done in a short time and are helpful in acute care.

3. Speed: Great news for those that require creatinine detection, immunoassays can be done in a short time and are helpful in acute care.

4. Cost-effectiveness: Thus, using creatinine immuno-diagnostics is cost-effective, which allows for a wide introduction of diagnostics in different types of healthcare.

5. Minimal Sample Requirements: Such tests usually need a small measure of blood to be drawn from the patient’s body hence the procedure is less challenging.

The creatinine antibodies and antigens are applied for accurate and fast diagnostic kits especially in cases where rapid and qualitative assessment of kidneys function is required.

How to use Creatinine Pair Antibody and Antigen in kidney function in different diagnostic platform (LFA, CLIA, POCT)?

1. Lateral Flow Assays (LFA): CLIAs of creatinine feature high sensitivity and specificity which make it very useful in the monitoring of acute and chronic kidney diseases.

2. Chemiluminescence Immunoassays (CLIA): CLIAs of creatinine feature high sensitivity and specificity which make it very useful in the monitoring of acute and chronic kidney diseases.

3. Point-of-Care Testing (POCT): routine creatinine measurements in point-of-care locations for directing the patient management by producing a rapid outcome indispensable in ameliorating renal emergencies.

4. Integration with Digital Health Tools: Present-day diagnostic schemes combine creatinine immunoassays with a digital signal that enables the instantaneous evaluation of a patient’s data away from the clinic.

These methods reveal how creatinine immuno-diagnostics can effectively integrate itself to the needs of patients and timely provide the latter with correct information about their kidney health status.