100 Hot Targets in Focus in 2024 | TarMart™-Insight
'100 Hot Targets in Focus in 2024 | TarMart™-Insight' showcases essential biological targets for drug development, therapy, and biotech. These targets, including proteins, genes, and cellular structures, are carefully chosen and analyzed for their potential value in advancing relevant fields.
The table is continuously updated to ensure it reflects the latest hot targets.
The data from our first edition:
TarMart™-Insight:
100 Potential Hot Targets , last refreshed in August 2023.
The data from our second edition:
100 Hot
Targets Spotlighted | TarMart™-Insight, last refreshed in October 2023.
|
Target ID |
Target |
Uniprot Accession |
Disease |
Publication Link |
Target Detail |
|
GM-T99732 |
FGF18 |
O76093 |
Cardiomegaly |
||
|
GM-T85540 |
KDM5C |
P41229 |
osteoporosis |
||
|
GM-T85273 |
FoxM1 |
Q08050 |
acute lung injury |
||
|
GM-T80454 |
Tiam1 |
Q13009 |
neuropathic pain |
||
|
GM-T79160 |
GDNF |
P39905 |
alcohol use disorder |
||
|
GM-T78567 |
OSMR |
Q99650 |
Muscle atrophy |
||
|
GM-T73756 |
EphB2 |
P29323 |
NASH |
||
|
GM-T68547 |
HDAC1 |
Q13547 |
chronic pain |
||
|
GM-T64205 |
STAT1 |
P42224 |
Cancer (triple negative breast cancer) |
||
|
GM-T63024 |
TBK1 |
Q9UHD2 |
Cancer (immunotherapy) |
||
|
GM-T58080 |
B2M |
P61769 |
down syndrome |
||
|
GM-T56505 |
CYR61 |
O00622 |
NASH |
||
|
GM-T53251 |
G9a |
Q96KQ7 |
Cancer (hepatoblastoma) |
||
|
GM-T51076 |
NTRK3 |
Q16288 |
NASH |
||
|
GM-T46482 |
TLR7 |
Q9NYK1 |
chronic obstructive pulmonary disease |
||
|
GM-T44991 |
VCAM1 |
P19320 |
Alzheimer's disease |
||
|
GM-T39519 |
SUV39H1 |
O43463 |
Cancer (CAR-T) |
||
|
GM-T35792 |
Smyd3 |
Q9H7B4 |
Alzheimer's disease |
||
|
GM-T35289 |
NKG2D |
P26718 |
Aging (CAR-T) |
||
|
GM-T33976 |
CD71 |
P02786 |
systemic lupus erythematosus |
||
|
GM-T33245 |
GDF15 |
Q99988 |
hyperemesis gravidarum |
||
|
GM-T30790 |
Orai1 |
Q96D31 |
neuropathic pain |
||
|
GM-T13928 |
NEDP1 |
Q96LD8 |
ALS |
||
|
GM-T07507 |
MYH7 |
P12883 |
Hypertrophic cardiomyopathy (Base editing therapy) |
||
|
GM-T07173 |
TrkA |
P04629 |
tendon injury |
||
|
GM-SE1394 |
HS3ST1 |
O14792 |
Alzheimer's disease |
||
|
GM-SE0987 |
IGFBP5 |
P24593 |
Cancer (glioblastoma) |
||
|
GM-SE0656 |
AGGF1 |
Q8N302 |
Thoracic aortic aneurysm |
||
|
GM-SE0640 |
ADAMTS14 |
Q8WXS8 |
obesity |
||
|
GM-MP2580 |
GSDMD |
P57764 |
systemic lupus erythematosus |
||
|
GM-MP2275 |
RAB27B |
O00194 |
Cancer (acute myeloid leukemia) |
||
|
GM-MP2216 |
NMT |
P30419 |
senescence |
||
|
GM-MP2056 |
CKAP5 |
Q14008 |
Cancer (ovarian cancer) |
||
|
GM-MP1916 |
VANGL2 |
Q9ULK5 |
Viral infection |
||
|
GM-MP1550 |
VGLUT1 |
Q9P2U7 |
central nervous system diseases |
||
|
GM-MP1483 |
SCARB2 |
Q14108 |
Cancer (hepatocellular carcinoma) |
||
|
GM-MP1478 |
RyR2 |
Q92736 |
chemo brain |
||
|
GM-MP1404 |
GPR10 |
P49683 |
obesity |
||
|
GM-MP1366 |
Piezo2 |
Q9H5I5 |
osteoarthritis pain |
||
|
GM-MP0874 |
NEU1 |
Q99519 |
kidney disease |
||
|
GM-MP0208 |
CD300ld |
Q6UXZ3 |
Cancer (immunotherapy) |
||
|
GM-IP1956 |
TMEM106B |
Q9NUM4 |
SARS-CoV-2 infection |
||
|
GM-IP1327 |
HPIP |
Q96AQ6 |
cancer |
||
|
GM-IP0248 |
IDH2 |
P48735 |
Cancer (CAR-T) |
||
|
|
CPSF3 |
Q9UKF6 |
Cancer (ovarian cancer) |
|
|
|
|
TRABID |
Q9UGI0 |
Cancer (immunotherapy) |
|
|
|
|
BATF3 |
Q9NR55 |
Cancer (CAR-T) |
|
|
|
|
PRDM6 |
Q9NQX0 |
hypertension |
|
|
|
|
ZBP1 |
Q9H171 |
heart failure |
|
|
|
|
YTHDF1 |
Q9BYJ9 |
obesity |
|
|
|
|
KDM5D |
Q9BY66 |
Cancer (colorectal cancer) |
|
|
|
|
TRIM11 |
Q96F44 |
Alzheimer's disease |
|
|
|
|
SUSD6 |
Q92537 |
cancer |
|
|
|
|
CCL4L2 |
Q8NHW4 |
asthma |
|
|
|
|
TET1 |
Q8NFU7 |
Cancer (B-ALL) |
|
|
|
|
MTr1 |
Q8N1G2 |
influenza |
|
|
|
|
THADA |
Q6YHU6 |
type 2 diabetes |
|
|
|
|
TAF15 |
Q16514 |
frontotemporal dementia |
|
|
|
|
PSME4 |
Q14997 |
Cancer (immunotherapy) |
|
|
|
|
Nsun2 |
Q08J23 |
autoimmune disease |
|
|
|
|
SYF2 |
O95926 |
ALS |
|
|
|
|
DRP1 |
O00429 |
cancer |
|
|
|
|
TUG1 |
A0A6I8PU40 |
cancer |
|
|
|
|
ALPL-1 |
A0A2H8TN21 |
Cancer (osteosarcoma, CAR-T) |
|
|
|
|
LSD1 |
A0A1P8B450 |
Spinobulbar muscular atrophy |
|
|
|
|
PRMT6 |
A0A1P8B451 |
Spinobulbar muscular atrophy |
|
|
|
|
HIF-2α |
Q99814 |
bone loss |
|
|
|
|
p38α |
Q16539 |
Lewy body disease |
|
|
|
|
miR-206-3p-CXCR4 |
P61073 |
atherosclerosis |
|
|
|
|
IL-4Rα |
P24394 |
Cancer (immunotherapy) |
|
|
|
|
TGFβ |
P01137 |
polycystic liver disease |
|
|
|
|
integrin |
P01137 |
polycystic liver disease |
|
|
|
|
netrin-1 |
O95631 |
cancer epithelial-mesenchymal transition |
|
|
|
|
IRE1α |
O75460 |
Cancer (KRAS inhibitor resistance) |
|
|
|
|
PKCδ |
|
Cancer (glioblastoma) |
|
|
|
|
KAT8 |
|
Cancer (immunotherapy) |
|
|
|
|
IRF1 |
|
Cancer (immunotherapy) |
|
|
|
|
GM |
|
glomerulus nephritis |
|
|
|
|
CSF |
|
glomerulus nephritis |
|
|
|
|
PRRS3 |
|
Cancer (hepatocellular carcinoma) |
|
|
|
|
glycoprotein 130 |
|
tissue regeneration |
|
|
|
|
VRAC |
|
neuropathic pain |
|
|
|
|
PRTM3 |
|
Cancer (hepatocellular carcinoma) |
|
|
|
|
IGF2BP1 |
|
Cancer (hepatocellular carcinoma) |
|
|
|
|
HEG3 axis |
|
Cancer (hepatocellular carcinoma) |
|
|
|
|
Gα+s–GPCRs |
|
Cancer (immunotherapy) |
|
|
|
|
Fzd5 |
|
lung damage |
|
|
|
|
Fzd6 |
|
lung damage |
|
|
|
|
TIM-1 |
|
Cancer (immunotherapy) |
|
|
|
|
FSP1 |
|
cancer |
|
|
|
|
PirB |
|
NASH |
|
|
|
|
LILRB2 |
|
NASH |
|
|
|
|
ANGPTL8 |
|
NASH |
|
|
|
|
MET404 |
|
Cancer (glioblastoma) |
|
|
|
|
cGAS |
|
neurodegenerative diseases |
|
|
|
|
STING |
|
neurodegenerative diseases |
|
|
|
|
Interferon-ε |
|
Cancer (ovarian cancer) |
|
|
|
|
Calprotectin |
|
Vascular Calcification |
|
|
|
|
SHP2 |
|
sarcoidosis |
|
|
|
|
MEG3 |
|
Alzheimer's disease |
|
|
|
|
D2D3 |
|
diabetes; kidney disease |
|
|
|
|
PSAM4 |
|
pain |
|
|
|
|
GlyR |
|
pain |
|
|
|
|
Integrin α3 |
|
multiple sclerosis |
|
|
|
|
MrgprB2 |
|
Alcohol withdrawal related headaches |
|
|
|
|
Canca2d1 |
|
obesity |
|
|
|
|
UBE2O |
|
Cancer (osteosarcoma) |
|
|
|
|
L3MBTL3 axis |
|
Cancer (osteosarcoma) |
|
|
|
|
MLCL |
|
Barth syndrome |
|
|
|
|
cyt c peroxidase |
|
Barth syndrome |
|
|
|
|
TSC1 |
|
Parkinson's Disease |
|
|
|
|
TSC2 |
|
Parkinson's Disease |
|
|
|
|
mTORC3 |
|
Parkinson's Disease |
|
|
|
|
Cav2.3 |
|
epilepsy |
|
|
|
|
cytochrome bc1 |
|
Visceral leishmaniasis |
|
TarMart™ is GeneMedi's all-in-one industry solution for therapeutic targets and diagnostics biomarkers. It leverages the robust capabilities of the GM-ITD database to provide an expansive portfolio of product solutions, encompassing a diverse array of target classes.
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