GeneMedi SOLIDEX™ Cell Therapy Solutions
GeneMedi offers a comprehensive one-stop solution covering cell separation, flow cytometry analysis, and CAR-T cell therapy development, empowering precision medicine research and clinical translation.
SOLIDEX™ Cell Therapy Solutions Detail
ISOEx Immunocytes Cell Isolation Immunomagnetic Beads
Function: High-purity enrichment of specific immune cells or stem cells for downstream experiments.
Core Technologies:
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Direct MACS: Antibody-conjugated beads for one-step cell isolation (e.g., CD3, CD4, CD8 T cells).
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Indirect MACS: Biotinylated antibodies + Streptavidin (SA)-conjugated beads for flexible multiplex sorting.
Product Highlights:
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Optimized antibodies targeting CD3, CD4, CD8, CD14, CD19, CD34, NK (CD56), monocytes (CD14), and more.
CDEx Flow Cytometry Antibodies
Function: Multiplexed, high-sensitivity analysis of immune cell phenotypes at the single-cell level.
Product Portfolio:
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PE/APC/FITC-Conjugated Antibodies: Targeting CD3E, CD4, CD8, CD14, CD19, NCAM1 (CD56), TCR αβ, and others.
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Naked Antibodies: Support custom labeling (e.g., biotin, fluorescent dyes).
Technical Advantages:
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Exceptional sensitivity and specificity for complex samples like PBMCs.
TAGEx CAR-Analytical Tools
Companion Detection Tools:
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CAR-Specific Antibodies: Targeting scFv (e.g., FMC63), VHH, G4S nanobodies, hinge/transmembrane domains, and intracellular signaling motifs.
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Quality Control: Simulated sample testing and reduced background signals (outperforms Company C).
Lentiviral Vector Services:
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Target Proteins: CD19 (leukemia), BCMA (multiple myeloma), Her2 (breast cancer), GPC3 (hepatocellular carcinoma), etc.
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Key Features: High transduction efficiency, low genotoxicity, and support for multi-gene payloads (≤6.5 kb).
Service Workflow:
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Lentivirus packaging → CAR-T cell engineering → Functional validation → Preclinical/clinical trial support
End-to-End Coverage
From cell isolation → phenotypic analysis → gene modification → functional validation.
Customization
Tailored solutions for antibody labeling, vector design, and target optimization.
Synergy
Immunomagnetic bead-based purification enhances flow cytometry accuracy; lentiviral systems ensure efficient CAR-T production.
Applications
Oncology immunotherapy, Autoimmune disease research, Rare disease modeling, CAR-T clinical pipeline development
SOLIDEX™ solution - Product list
- ISOEx Immunocytes Cell Isolation Immunomagnetic Beads
- CDEx Flow Cytometry antibodies
- TAGEx CAR-Analytical Tools
Direct Magnetic Activated Cell Separation
Antibodies are directly conjugated to magnetic beads, enabling rapid, one-step cell isolation.Ideal for: Fast and efficient enrichment of target cells (e.g., CD4+ T cells, CD8+ T cells, CD34+ stem cells) with minimal handling.
| Cat No | Product Name | Species | Size | Cell population | Products Information |
|---|---|---|---|---|---|
| GM-Tg-hg-MP0250-Ab-3-nanoIMB | Human CD66b Nano-Immunomagnetic Bead | humanized | 1ml, 5ml, 10ml | Granulocyte | Details |
| GM-Tg-hg-T66426-Ab-3/4/7/8-nanoIMB | Human CD34 Nano-Immunomagnetic Bead | humanized | 1ml, 5ml, 10ml | Hematopoietic Stem Cell | Details |
| GM-Tg-hg-T86323-Ab-1-nanoIMB | Human NCAM1 (CD56) Nano-Immunomagnetic Bead | mouse | 1ml, 5ml, 10ml | NK cell | Details |
| GM-Tg-hg-T23212-Ab-1-nanoIMB | Human CD14 Nano-Immunomagnetic Bead | mouse | 1ml, 5ml, 10ml | Monocyte/Macrophage | Details |
| GM-Tg-hg-T56365-Ab-1-nanoIMB | Human CD19 Nano-Immunomagnetic Bead | mouse | 1ml, 5ml, 10ml | Bcell | Details |
| GM-Tg-hg-T87075-Ab-1-nanoIMB | Human CD3E Nano-Immunomagnetic Bead | mouse | 1ml, 5ml, 10ml | Pan-T cell | Details |
| GM-Tg-hg-T10191-Ab-1/2-nanoIMB | Human CD4 Nano-Immunomagnetic Bead | mouse | 1ml, 5ml, 10ml | CD4-T | Details |
| GM-Tg-hg-TA040-Ab-1-nanoIMB | Human CD8 Nano-Immunomagnetic Bead | mouse | 1ml, 5ml, 10ml | CD8-T | Details |
| GM-Tg-hg-MP2610-Ab-3-nanoIMB | Human TCR alpha-beta (abT) Nano-Immunomagnetic Bead | humanized | 1ml, 5ml, 10ml | Alpha-Beta T Cell | Details |
| GM-Tg-hg-T13017-Ab-1-nanoIMB | Human CD138 Nano-Immunomagnetic Bead | mouse | 1ml, 5ml, 10ml | Plasma Cell | Details |
| GM-Tg-hg-T43115-8-Ab-4-nanoIMB | Human CD45RA Nano-Immunomagnetic Bead | humanized | 1ml, 5ml, 10ml | Allhematopoietic cls | Details |
| GM-Tg-hg-T43115-Ab-4-nanoIMB | Human CD45 Nano-Immunomagnetic Bead | humanized | 1ml, 5ml, 10ml | Allhematopoietic cls | Details |
| GM-Tg-hg-T59001-Ab-3-nanoIMB | Human CD16 Nano-Immunomagnetic Bead | humanized | 1ml, 5ml, 10ml | NK cells | Details |
Indirect Magnetic Activated Cell Separation
Antibodies are biotinylated, allowing secondary capture via streptavidin (SA)-coupled magnetic beads.Ideal for: Multiplex labeling, sequential isolation, or when using antibodies not available in direct magnetic bead format.
| Cat No | Product Name | Species | Size | Cell population | Products Information |
|---|---|---|---|---|---|
| GM-Tg-hg-MP0250-Ab-3-Biotin | Biotin-conjugated Anti-Human CD66b monoclonal antibody(mAb) | humanized | 25T, 100T, 500T | Granulocyte | Details |
| GM-Tg-hg-T66426-Ab-3/4/7/8-Biotin | Biotin-conjugated Anti-Human CD34 monoclonal antibody(mAb) | humanized | 25T, 100T, 500T | Hematopoietic Stem Cell | Details |
| GM-Tg-hg-T86323-Ab-1-Biotin | Biotin-conjugated Anti-Human NCAM1 (CD56) monoclonal antibody(mAb) | mouse | 25T, 100T, 500T | NK cell | Details |
| GM-Tg-hg-T23212-Ab-1-Biotin | Biotin-conjugated Anti-Human CD14 monoclonal antibody(mAb) | mouse | 25T, 100T, 500T | Monocyte/Macrophage | Details |
| GM-Tg-hg-T56365-Ab-1-Biotin | Biotin-conjugated Anti-Human CD19 monoclonal antibody(mAb) | mouse | 25T, 100T, 500T | Bcell | Details |
| GM-Tg-hg-T87075-Ab-1-Biotin | Biotin-conjugated Anti-Human CD3E monoclonal antibody(mAb) | mouse | 25T, 100T, 500T | Pan-T cell | Details |
| GM-Tg-hg-T10191-Ab-1/2-Biotin | Biotin-conjugated Anti-Human CD4 monoclonal antibody(mAb) | mouse | 25T, 100T, 500T | CD4-T | Details |
| GM-Tg-hg-TA040-Ab-1-Biotin | Biotin-conjugated Anti-Human CD8 monoclonal antibody(mAb) | mouse | 25T, 100T, 500T | CD8-T | Details |
| GM-Tg-hg-MP2610-Ab-3-Biotin | Biotin-conjugated Anti-Human TCR alpha-beta (abT) monoclonal antibody(mAb) | humanized | 25T, 100T, 500T | Alpha-Beta T Cell | Details |
| GM-Tg-hg-T13017-Ab-1-Biotin | Biotin-conjugated Anti-Human CD138 monoclonal antibody(mAb) | mouse | 25T, 100T, 500T | Plasma Cell | Details |
| GM-Tg-hg-T43115-8-Ab-4-Biotin | Biotin-conjugated Anti-Human CD45RA monoclonal antibody(mAb) | humanized | 25T, 100T, 500T | Allhematopoietic cls | Details |
| GM-Tg-hg-T43115-Ab-4-Biotin | Biotin-conjugated Anti-Human CD45 monoclonal antibody(mAb) | humanized | 25T, 100T, 500T | Allhematopoietic cls | Details |
| GM-Tg-hg-T59001-Ab-3-Biotin | Biotin-conjugated Anti-Human CD16 monoclonal antibody(mAb) | humanized | 25T, 100T, 500T | NK cells | Details |
| GMP-SMT-1766-nanoIMB | Nano-lmmunomaqnetic Bead-Streptavidin (SA) | N/A | 1ml, 5ml, 10ml | N/A | Details |
CDEx Flow Cytometry Antibodies
Fluorescent-Conjugated Antibodies (PE/APC/FITC). These antibodies are conjugated to fluorescent dyes, such as Phycoerythrin (PE), Allophycocyanin (APC), or Fluorescein Isothiocyanate (FITC), making them particularly valuable for flow cytometry and multi-parameter analysis. Fluorescent labeling allows researchers to investigate specific cell populations by enabling the detection of markers on individual cells at a high sensitivity. Each dye has unique excitation and emission spectra, enabling multiplexing in a single experiment for a detailed and comprehensive analysis.
| Cat No | Product Name | Speices | Conjugate | Size | Cell population | Products Information |
|---|---|---|---|---|---|---|
| GM-Tg-hg-MP0250-Ab-3-PE/FITC/APC | Anti-Human CD66b monoclonal antibody(mAb)(PE/FITC/APC) | humanized | PE/FITC/APC | 25T, 100T, 500T | Granulocyte | Details |
| GM-Tg-hg-T66426-Ab-3/4/7/8-PE/FITC/APC | Anti-Human CD34 monoclonal antibody(mAb)(PE/FITC/APC) | humanized | PE/FITC/APC | 25T, 100T, 500T | Hematopoietic Stem Cell | Details |
| GM-Tg-hg-T86323-Ab-1-PE/FITC/APC | Anti-Human NCAM1 (CD56) monoclonal antibody(mAb)(PE/FITC/APC) | mouse | PE/FITC/APC | 25T, 100T, 500T | NK cell | Details |
| GM-Tg-hg-T23212-Ab-1-PE/FITC/APC | Anti-Human CD14 monoclonal antibody(mAb)(PE/FITC/APC) | mouse | PE/FITC/APC | 25T, 100T, 500T | Monocyte/Macrophage | Details |
| GM-Tg-hg-T56365-Ab-1-PE/FITC/APC | Anti-Human CD19 monoclonal antibody(mAb)(PE/FITC/APC) | mouse | PE/FITC/APC | 25T, 100T, 500T | Bcell | Details |
| GM-Tg-hg-T87075-Ab-1-PE/FITC/APC | Anti-Human CD3E monoclonal antibody(mAb)(PE/FITC/APC) | mouse | PE/FITC/APC | 25T, 100T, 500T | Pan-T cell | Details |
| GM-Tg-hg-T10191-Ab-1/2-PE/FITC/APC | Anti-Human CD4 monoclonal antibody(mAb)(PE/FITC/APC) | mouse | PE/FITC/APC | 25T, 100T, 500T | CD4-T | Details |
| GM-Tg-hg-TA040-Ab-1-PE/FITC/APC | Anti-Human CD8 monoclonal antibody(mAb)(PE/FITC/APC) | mouse | PE/FITC/APC | 25T, 100T, 500T | CD8-T | Details |
| GM-Tg-hg-MP2610-Ab-3-PE/FITC/APC | Anti-Human TCR alpha-beta (abT) monoclonal antibody(mAb)(PE/FITC/APC) | humanized | PE/FITC/APC | 25T, 100T, 500T | Alpha-Beta T Cell | Details |
| GM-Tg-hg-T13017-Ab-1-PE/FITC/APC | Anti-Human CD138 monoclonal antibody(mAb)(PE/FITC/APC) | mouse | PE/FITC/APC | 25T, 100T, 500T | Plasma Cell | Details |
| GM-Tg-hg-T43115-8-Ab-4-PE/FITC/APC | Anti-Human CD45RA monoclonal antibody(mAb)(PE/FITC/APC) | humanized | PE/FITC/APC | 25T, 100T, 500T | Allhematopoietic cls | Details |
| GM-Tg-hg-T43115-Ab-4-PE/FITC/APC | Anti-Human CD45 monoclonal antibody(mAb)(PE/FITC/APC) | humanized | PE/FITC/APC | 25T, 100T, 500T | Allhematopoietic cls | Details |
| GM-Tg-hg-T59001-Ab-3-PE/FITC/APC | Anti-human CD16 human monoclonal antibody(mAb)(PE/FITC/APC) | humanized | PE/FITC/APC | 25T, 100T, 500T | NK cells | Details |
Naked Antibodies
These are unmodified, purified antibodies that have no additional labels or conjugations. Naked antibodies are ideal for applications where labeling is not required, such as binding studies, neutralization assays, and situations where the researcher may want to customize the antibody with a specific label. They offer flexibility, as they can be tailored to the researcher's needs for labeling or further conjugation.
| Cat No | Product Name | Species | Products Information |
|---|---|---|---|
| GM-Tg-hg-MP0250-Ab-3 | Anti-Human CD66b monoclonal antibody(mAb) | humanized | Details |
| GM-Tg-hg-T66426-Ab-3/4/7/8 | Anti-Human CD34 monoclonal antibody(mAb) | humanized | Details |
| GM-Tg-hg-T86323-Ab-1 | Anti-Human NCAM1 (CD56) monoclonal antibody(mAb) | mouse | Details |
| GM-Tg-hg-T23212-Ab-1 | Anti-Human CD14 monoclonal antibody(mAb) | mouse | Details |
| GM-Tg-hg-T56365-Ab-1 | Anti-Human CD19 monoclonal antibody(mAb) | mouse | Details |
| GM-Tg-hg-T87075-Ab-1 | Anti-Human CD3E monoclonal antibody(mAb) | mouse | Details |
| GM-Tg-hg-T10191-Ab-1/2 | Anti-Human CD4 monoclonal antibody(mAb) | mouse | Details |
| GM-Tg-hg-TA040-Ab-1 | Anti-Human CD8 monoclonal antibody(mAb) | mouse | Details |
| GM-Tg-hg-MP2610-Ab-3 | Anti-Human TCR alpha-beta (abT) monoclonal antibody(mAb) | humanized | Details |
| GM-Tg-hg-T13017-Ab-1 | Anti-Human CD138 monoclonal antibody(mAb) | mouse | Details |
| GM-Tg-hg-T43115-8-Ab-4 | Anti-Human CD45RA monoclonal antibody(mAb) | humanized | Details |
| GM-Tg-hg-T43115-Ab-4 | Anti-Human CD45 monoclonal antibody(mAb) | humanized | Details |
| GM-Tg-hg-T59001-Ab-3 | Anti-human CD16 human monoclonal antibody(mAb) | humanized | Details |
TAGEx CAR-Analytical Tools
The GeneMedi still aims to supply the superior CAR-T cell preparation service together with a plethora of valuable CAR detection kits, which are fundamental for accurate enumeration and comprehensive investigation of CAR-T cell therapies. The assortment presented would provide both researchers and clinicians with a full spectrum of reagents and antibodies necessary to characterize CAR-T cells at each step of the process.
For the proper detection of These CAR-T cell treatments, the GeneMedi portfolio features antibodies specific to different parts of the CAR construct; scFv, hinge, transmembrane and the intracellular signal domains. It is also presupposed that with the help of this range, possible changes in CAR expression, assembly, and function can be studied comprehensively to understand how the CAR-T cells behave after infusion and engage tumor cells.
To directly detect CAR expression, the antibodies employed in this method are designed to specifically bind novel epitopes that are part of the scFv of the CAR, allowing assessment of CAR-T cell numbers in patients' circulation. This is important for the overall assessment of CAR-T cells and their sustainability after the treatment, which gives an indication of the success of the particular therapy type.
| Cat No | Products name | Products description | Detail |
| GMLS-Tag003-Ab01 | Anti-G4S Linker monoclonal antibody | This antibody is expertly crafted to detect the G4S linker within CAR constructs, providing a reliable tool for monitoring CAR expression and ensuring the efficacy of CAR-T cell therapies. | Details |
| GTU-ADA-FMC63-Ab01~06 | Anti-FMC63 monoclonal antibody | Specifically targeting the FMC63 scFv used in CD19 CAR constructs, this antibody plays a crucial role in assessing the specificity and functionality of CD19-directed CAR-T cells, highlighting our focus on delivering precision in CAR-T cell therapy. | Details |
| GMLS-Tag002-Ab01 | Anti-VHH monoclonal antibody | Designed to recognize VHH domains, this antibody is a pivotal tool in the detection and analysis of CAR constructs that incorporate VHH domains. It offers a highly specific and sensitive means of verifying the presence and functionality of these innovative CAR constructs. | Details |
Validation Data
- ISOEx Immunocytes Cell Isolation Immunomagnetic Beads
- CDEx Flow Cytometry Antibodies
- TAGEx CAR-Analytical Tools
ISOEx Immunocytes Cell Isolation Immunomagnetic Beads
Efficient Isolation of Jurkat Cells Using GeneMedi's Indirect TCRα/β T Cell Isolation Kit
To evaluate the performance of GeneMedi's Indirect TCRα/β T Cell Isolation Kit, Jurkat cells were mixed with 293T-GFP cells at a 1:2 ratio, followed by magnetic separation using both GeneMedi's kit and a competitor's (Company M's TCRα/β T Cell Isolation Kit). The purity of isolated Jurkat cells was assessed via flow cytometry analysis. GeneMedi's Indirect TCRα/β T Cell Isolation Kit delivers superior cell isolation performance.
Figure 1. Efficient Isolation of Jurkat Cells Using GeneMedi's Indirect TCRα/β T Cell Isolation Kit.
The flow cytometry analysis of the purified Jurkat cells by using Company M's TCRα/β T Cell isolation kit and GeneMedi's indirect TCRα/β T Cell isolation kit.
High-Purity Isolation of TCRα/β+ T Cells from Human PBMCs Using GeneMedi's Indirect TCRα/β T Cell Isolation Kit
Human peripheral blood mononuclear cells (PBMCs) were freshly recovered and subjected to TCRα/β+ T cell isolation using GeneMedi's Indirect TCRα/β T Cell Isolation Kit and Company M's TCRα/β T Cell kit. The isolated cell population was analyzed by flow cytometry to evaluate purity and efficiency. GeneMedi's Indirect TCRα/β T Cell Isolation Kit provides superior performance in isolating TCRα/β+ T cells from human PBMCs, delivering high purity and yield for downstream applications.
Figure 2. High-Purity Isolation of TCRα/β+ T Cells from Human PBMCs Using GeneMedi's Indirect TCRα/β T Cell Isolation Kit.
The flow cytometry analysis of the isolated cells from cryopreserved PBMCs.
SOLIDEX™-CDEx Flow Cytometry antibodies
GeneMedi's Flow Cytometry antibodies are validated to detect PBMC-derived specific cell types by flow cytometry.
GeneMedi's antibodies—Anti-Human CD3E, Anti-Human CD4, Anti-Human CD8, Anti-Human CD14, Anti-Human CD19, and Anti-Human NCAM1 (CD56)—are extensively validated for the detection of specific cell types derived from Peripheral Blood Mononuclear Cells (PBMCs) by flow cytometry. These antibodies enable accurate identification and profiling of immune cell subsets within PBMC populations, supporting diverse immunological studies and applications. These antibodies perform reliably in identifying critical immune cell subsets, including T cells, B cells, monocytes, and natural killer (NK) cells, providing essential tools for immunological and therapeutic research.
Comparative studies indicate that GeneMedi's antibody products offer performance on par with Company B's commercial antibodies. This similarity in performance means that researchers can expect comparable levels of sensitivity, specificity, and consistency when using GeneMedi's antibodies. Such equivalency provides researchers with confidence in using GeneMedi's products as effective alternatives, whether for immune profiling, cell population analysis, or functional assays.
Figure 1. GeneMedi's Anti-Human CD3E antibody, Anti-Human CD4 antibody, Anti-Human CD8 antibody, Anti-Human CD14 antibody, Anti-Human CD19 antibody, Anti-Human CD56 antibody, Anti-Human CD45 monoclonal antibody, Anti-Human CD66b monoclonal antibody and Anti-Human CD34 monoclonal antibody are validated to detect PBMC-derived specific cell types byflow cytometry.
A-F. Anti-Human CD3E antibody (A), Anti-Human CD4 antibody (B), Anti-Human CD8 antibody (C), Anti-Human CD14 antibody (D), Anti-Human CD19 antibody (E), Anti-Human NCAM1 (CD56) antibody (F).
G. The Cat number and product name correspond to the antibodies used in this study.
Figure 2. The GTU-ADA-FMC63-Ab01 and GMLS-Tag003-Ab-1 are validated to detect CAR-NK cells.
Figure 3. The GTU-ADA-FMC63-Ab01 is validated to detect Simulate samples of CAR-NK infusion in patients.
Figure 4. For detecting CAR-T cells, GeneMedi's GMLS-Tag003-Ab-1 detection background is lower, and the detection results are closer to specific antigen detection, compared to Company C.
GMLS-Tag002-Ab01 effectively detects VHH-based format ant-Target CAR expression with great consistency with the target protein
Target protein (antigen) is usually used to detect anti-target CAR expression. For example, CD19 recombinant protein is used as a detection antigen for CAR position rate detection. However, the target protein is unique, expensive, and hard to produce. GeneMedi's anti-VHH antibody is a universal strategy for the detection of VHH-based format anti-Target CAR expression.
293T cells were transfected with CAR plasmids expressing VHH antibodies specific to target1, target2, target3, and target4. Following transfection, the expression of the corresponding CARs was confirmed using the specific recombinant proteins, GMLS-Tag002-Ab01, and a commercial Anti-VHH antibody (Company G).
The recombinant proteins were used as positive controls to benchmark CAR-positive detection. Statistical Analysis uses the positive detection ratio of GMLS-Tag002-Ab01 or Anti-VHH antibody (Company G) relative to the antigen-based detection. GMLS-Tag002-Ab01 achieves a consistency ratio close to 1.0. The data shows that the positive detection rate with GMLS-Tag002-Ab01 was comparable to that of the antigens, demonstrating nearly identical performance to the positive control. In contrast, the anti-VHH antibody (Company G) exhibited higher or lower detection sensitivity. The results indicate that GMLS-Tag002-Ab01 effectively detects the expressed VHH antibodies (nanobody, VHH-based bispecific antibody) on CAR-transfected 293T cells with high accuracy, comparable to the recombinant proteins. This establishes GMLS-Tag002-Ab01 as a reliable tool for detecting CAR expression in similar experiments.
Figure 5. GMLS-Tag002-Ab01 effectively evaluates the expression of anti-Target nanobody (VHH) on CAR-transfected 293T cells with higher specificity in flow cytometry.
A. The scatter plot shows the fluorescence intensity of CAR-expressing 293T cells stained with GMLS-Tag002-Ab01, Anti-VHH antibody (Company G), and the specific recombinant target protein (positive control).
B. GeneMedi's anti-VHH antibody shows great consistency with the antigen-based evaluation strategy in VHH-based format CAR expressing cell QC. Statistical Analysis uses the positive detection ratio of GMLS-Tag002-Ab01 or Anti-VHH antibody from Company G relative to the target protein-based detection.
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