Anti-SULF2/ HSULF-2 monoclonal antibody
Anti-SULF2/ HSULF-2 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T86321-Ab-1/ GM-Tg-hg-T86321-Ab-2 | Anti-Human SULF2 monoclonal antibody | Human |
GM-Tg-rg-T86321-Ab-1/ GM-Tg-rg-T86321-Ab-2 | Anti-Rat SULF2 monoclonal antibody | Rat |
GM-Tg-mg-T86321-Ab-1/ GM-Tg-mg-T86321-Ab-2 | Anti-Mouse SULF2 monoclonal antibody | Mouse |
GM-Tg-cynog-T86321-Ab-1/ GM-Tg-cynog-T86321-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SULF2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T86321-Ab-1/ GM-Tg-felg-T86321-Ab-2 | Anti-Feline SULF2 monoclonal antibody | Feline |
GM-Tg-cang-T86321-Ab-1/ GM-Tg-cang-T86321-Ab-2 | Anti-Canine SULF2 monoclonal antibody | Canine |
GM-Tg-bovg-T86321-Ab-1/ GM-Tg-bovg-T86321-Ab-2 | Anti-Bovine SULF2 monoclonal antibody | Bovine |
GM-Tg-equg-T86321-Ab-1/ GM-Tg-equg-T86321-Ab-2 | Anti-Equine SULF2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T86321-Ab-1/ GM-Tg-hg-T86321-Ab-2; GM-Tg-rg-T86321-Ab-1/ GM-Tg-rg-T86321-Ab-2; GM-Tg-mg-T86321-Ab-1/ GM-Tg-mg-T86321-Ab-2; GM-Tg-cynog-T86321-Ab-1/ GM-Tg-cynog-T86321-Ab-2; GM-Tg-felg-T86321-Ab-1/ GM-Tg-felg-T86321-Ab-2; GM-Tg-cang-T86321-Ab-1/ GM-Tg-cang-T86321-Ab-2; GM-Tg-bovg-T86321-Ab-1/ GM-Tg-bovg-T86321-Ab-2; GM-Tg-equg-T86321-Ab-1/ GM-Tg-equg-T86321-Ab-2 |
Products Name | Anti-SULF2 monoclonal antibody |
Format | mab |
Target Name | SULF2 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-SULF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species SULF2/ HSULF-2 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP001432 | human SULF2 Lentivirus particle |
ORF Viral Vector | pGMLP001432 | human SULF2 Lentivirus plasmid |
Target information
Target ID | GM-T86321 |
Target Name | SULF2 |
Gene ID | 55959,72043,311642,715937,477254,101083072,533264,100056840 |
Gene Symbol and Synonyms | 2010004N24Rik,HSULF-2,mKIAA1247,MSulf-2,SULF2 |
Uniprot Accession | Q8IWU5 |
Uniprot Entry Name | SULF2_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000196562 |
Target Classification | N/A |
The target: SULF2, gene name: SULF2, also named as HSULF-2. Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.