Anti-small molecules (Chemicals, Antibiotics,Mycotoxins,etc.) antibodies and small molecules
competitive antigens
(Carrier-coupled antigen, immunogen, hapten-carrier conjugates,
BSA-conjugated, OVA-conjugated), competitive ELISA validated
Competitive immunoassay-validated anti-Hapten(small molecules, chemicals) antibody against
hapten (small molecules, chemicals) and hapten-carrier conjugated competitive
antigens(Carrier-coupled antigen,immunogen,hapten-carrier conjugates, BSA-conjugated,
OVA-conjugated).
The anti-Hapten antibodies against haptens had been validated with our hapten-carrier conjugates
via competitive ELISA test.
GeneMedi offers paired anti-small molecules (Chemicals, Antibiotics,Mycotoxins,Hormones,Drugs of
Abuse, etc.) antibodies (monoclonal antibody, mab) and small molecules competitive antigens
(Carrier-coupled antigen, immunogen, hapten-carrier conjugates, BSA-conjugated, OVA-conjugated)
for the rapid test and diagnostics kit of Growth Promoters, Toxic Heavy Metal,
Myotoxins,Nutritions, Food Safety, Pesticides, Drugs of Abuse, Allergen, Antibiotics,
Agricultural, Water Contamination and so on.
All our anti-chemicals antibodies and small molecules hapten-carrier conjugates antigens
(BSA-conjugated, OVA-conjugated)are suitable for in competitive ELISA, Lateral flow immunoassay
(LFIA) and other immunoassays in diagnostics and rapid test kit. The carrier-coupled antigens of
small molecules can act as immunogens.
Trimethoprim is a synthetic derivative of trimethoxybenzyl-pyrimidine with antibacterial and
antiprotozoal properties. Sulfamethoxazole with trimethoprim is a fixed antibiotic combination
that is widely used for mild-to-moderate bacterial infections and as prophylaxis against
opportunistic infections. Recently, our R&D department demonstrated that our GMP-SMT-73-Ab-1
(Anti-Trimethoprim(TMP) mouse monoclonal antibody) has a large linear range and good sensitivity
against the GMP-SMT-73-Ag-1 (BSA-Trimethoprim(TMP)). Below is the result of GeneMedi's
Anti-Trimethoprim(TMP) mouse monoclonal antibody validation with BSA-Trimethoprim(TMP) in ELISA.
We highly recommend the Ab&Ag to you.
Figure 1. GeneMedi's GMP-SMT-73-Ab-1 (Anti-Trimethoprim(TMP) mouse monoclonal antibody)
is validated to detect the GMP-SMT-73-Ag-1 (BSA-Trimethoprim(TMP)) in ELISA. EC50 = 234.5
ng/ml.
Genemedi supplies Small Molecule Diagnostic for a wide selection of choices (please see
below).
Antibiotics
Food Safety
Agricultural
Allergen
Mycotoxins
Drugs of Abuse
Toxic Heavy Metal
Hormones
Chemicals
Vitamins
Amino Acids
IVD
Antibiotics
Antibiotics have been used in animal husbandry for growth promotion and treatment of infections
since their inception for human medicine. This is especially important in intensive animal
farming methods where there is a higher risk of antibiotic residues in foods such as raw milk,
poultry, cattle, pork, fish, etc. The presence of antimicrobial residues (AR) in farm foods
poses a significant risk of allergic reactions, toxicity, carcinogenic effects, selection of
resistant bacteria, disruption of human normal flora, provoke immunological response, and
inhibition of starter cultures. Developing countries have a higher risk of residues due to a
lack of detection facilities and regulatory bodies for controlling drug residue levels in food
in the form of maximum residue limits (MRLs). To prevent/minimize the risk of antimicrobial
residue in milk, different methods of detection of residue to the standard limit level in all
food items are possible by chemical, microbiological, and immunological assays. Genemedi has
developed antibodies and antigens to detect the MRL of various antibiotics in food such as raw
milk, poultry, cattle, pork, fish, etc. Different samples may require different detection
methods such as ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic
assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immunoassay (TINIA),
immunonephelometry, and POCT.
Antibiotics are chemical compounds produced by microorganisms such as bacteria and fungi that
can kill or inhibit the growth of other microorganisms. Since their discovery in the early 20th
century, antibiotics have revolutionized the field of medicine significantly, improving the
outcome for patients suffering from bacterial infections. Several classes of antibiotics are
commonly used in clinical practice, including beta-lactams, macrolides, tetracyclines,
aminoglycosides, and fluoroquinolones, targeting different aspects of bacterial cell physiology,
making them effective against specific types of bacteria. The mode of action of many antibiotics
involves binding to specific proteins within the bacterial cell, such as beta-lactam antibiotics
that bind to the penicillin-binding proteins (PBPs) involved in peptidoglycan synthesis, causing
the bacterial cell wall to break down. Macrolide antibiotics bind to the 50S ribosomal subunit,
impeding protein synthesis and killing the bacteria.
Apart from their therapeutic use, antibiotics are essential tools for diagnostics. The
susceptibility of bacteria to antibiotics can be tested in the laboratory, allowing physicians
to choose the most suitable antibiotic for treating a particular infection. This is critical in
light of the growing problem of antibiotic resistance, where bacteria evolve mechanisms to evade
the effects of antibiotics. Emerging techniques such as anti-small molecule antibodies and small
molecule competitive antigens hold promise in enhancing the effectiveness of antibiotics.
Antibodies produced by the body's immune system are capable of recognizing and binding to
specific molecules, including antibiotics, thereby increasing their efficacy and reducing side
effects. Small molecule competitive antigens work by mimicking the structure of the antibiotic
molecule and competing for binding sites on the bacterial protein, preventing the bacteria from
developing resistance. Overall, antibiotics are indispensable in modern medicine and the
continued development of new tools like anti-small molecule antibodies and small molecule
competitive antigens holds great promise for improving their efficacy and mitigating the risk of
antibiotic resistance.
Maximum
Residue Limits (MRLs) for Veterinary Drugs in Foods.
Food safety
Ensuring food safety is a major global concern, and reliable diagnostics and therapeutics are
essential in this field. One promising area of research is the utilization of anti-small
molecule antibodies and small molecule competitive antigens as diagnostic tools. These
antibodies are capable of targeting small molecule compounds such as antibiotics or caffeine
present in food products, and have diverse applications in the detection of contaminants or
allergens in food products. Small molecule competitive antigens, being short molecules that can
mimic the structure of the target analytes, compete with target analytes to bind to an antibody,
enabling the quantification and detection of the analyte. Food safety can be segmented into
various categories, including microbiological, physical, and chemical, each aiming to identify
specific proteins or molecules involved in contaminating food products. Antibodies that target
specific molecules, such as pesticides, heavy metals, or antibiotics, as well as small molecule
competitive antigens, are valuable for detection and quantification purposes. Physical food
safety relies on identifying foreign objects such as metal or glass shards in food products,
whereas microbiological food safety focuses on detecting pathogenic microorganisms, including
Salmonella or E.coli, in foods. Antibodies that target specific structures or surfaces of these
microorganisms can aid in their detection.
Overall, anti-small molecule antibodies and small molecule competitive antigens hold significant
promise for enhancing food safety. These targeted tools offer highly sensitive and specific
approaches to identifying contaminants or allergens in food products. GeneMedi has developed
antigens and antibodies to detect various small molecules for food safety applications. A
variety of techniques may be employed to detect small molecules associated with food safety,
including ELISA, Lateral Flow Immunoassay (LFIA), colloidal gold immunochromatographic assay,
Chemiluminescent Immunoassay (CLIA), turbidimetric inhibition immunoassay (TINIA),
immunonephelometry, and POCT. As research in this field advances, we can expect to see more
innovative and effective diagnostic and therapeutic solutions for ensuring safe food
products.
Agricultural
Antibodies and antigens have found numerous applications in the agricultural sector, including
their use in diagnostic assays to detect pathogens and maintain food safety. Antibodies can be
developed against toxins produced by bacteria and viruses that contaminate food products,
providing a targeted approach for identifying and detecting potential hazards. Small molecules,
such as competitive antigens, can also be employed to develop diagnostic assays for pesticides,
herbicides, and other contaminants in fruits and vegetables. This enables the monitoring of
these substances in the food production process, ensuring the safety of agricultural products
for human consumption.
The specificity and versatility of antibodies and small molecules make them highly useful in the
detection and treatment of diseases and contaminants in agricultural products. For example,
Genemedi has developed the antigen and antibody to detect various small molecules of
agricultural origin, such as antibiotics, residues, and hormones, in different samples. The
detection of these small molecules is crucial in ensuring the safety and quality of agricultural
products, including raw milk, poultry, cattle, pork, fish, and other foods. Different methods of
detection, such as ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic
assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immunoassay (TINIA),
immunonephelometry, and POCT, may be used to analyze these samples.
Antibodies and small molecules have also become powerful tools in the field of therapeutics,
with promising applications in enhancing the effectiveness of antibiotics and mitigating the
risk of antibiotic resistance. By targeting antibiotics with antibodies, it may be possible to
increase their concentration at the site of infection, leading to better efficacy and fewer side
effects. Small molecule competitive antigens work by mimicking the structure of the antibiotic
molecule, preventing bacteria from developing resistance and promoting their
effectiveness.
In conclusion, antibodies and antigens have revolutionized the field of agriculture, providing a
targeted approach for identifying and detecting potential hazards in food products. With their
specificity and versatility, these molecules have become essential tools in diagnostics and
therapeutics for disease and contaminant detection. Their continued development, such as
Genemedi's cutting-edge methods for detecting agricultural small molecules, holds great promise
for further improving the quality and safety of agricultural products while mitigating health
risks for humans and animals alike.
Allergen
Allergens are substances capable of inducing an immune response that results in allergic
reactions in humans or animals. Sources of allergens are widespread and include pollen, dust
mites, food, and medications, among others. The identification and targeting of specific
allergenic molecules have led to the development of several diagnostic and therapeutic
applications. GeneMedi's anti-small molecule antibodies and small molecules competitive antigens
offer the potential to revolutionize allergen diagnostics and therapeutics, as they have shown
high specificity and efficacy in recognizing and neutralizing allergenic molecules and
preventing allergic reactions.
Allergens can be broadly classified into three primary categories: respiratory, food, and
contact. Each category comprises several important proteins with distinct functions and
therapeutic applications. Respiratory allergies are commonly caused by allergenic molecules such
as pollen, animal dander, and dust mites. The identification and targeting of specific
respiratory allergens have led to the development of several drugs such as antihistamines and
intranasal corticosteroids. GeneMedi's anti-small molecules antibodies and small molecules
competitive antigens product can also be utilized in the development of diagnostic assays for
the detection and quantification of respiratory allergens.
Food allergies can cause mild skin reactions to life-threatening anaphylaxis and are commonly
caused by allergenic molecules such as peanuts, milk, eggs, and shellfish. GeneMedi's product
can be employed in the development of therapeutic interventions, such as immunotherapy, which
involves exposing the patient to gradually increasing doses of the allergen to build immunity.
For contact allergies, common allergenic molecules include poison ivy, latex, and certain
metals, among others. GeneMedi's product can be utilized in the development of diagnostic assays
for the detection of these allergenic molecules, as well as in the development of topical creams
or gels for the treatment of contact dermatitis.
Overall, GeneMedi's anti-small molecule antibodies and small molecules competitive antigens
product offer significant potential in the field of allergen diagnostics and therapeutics. The
classification and identification of specific allergenic molecules offer opportunities for
precision medicine and personalized therapies. GeneMedi's product has the potential to
revolutionize the diagnosis and treatment of allergies, thereby improving patient outcomes and
quality of life. Genemedi has developed several methods for detecting allergenic molecules,
including ELISA, lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay,
chemiluminescent immunoassay (CLIA), turbidimetric inhibition immunoassay (TINIA),
immunonephelometry, and POCT, making it possible to detect allergenic molecules from different
samples.
Mycotoxins
Mycotoxins are secondary metabolites produced by fungi that can grow on various food crops,
particularly grains, nuts, and seeds. Mycotoxins can cause a wide range of adverse effects on
human and animal health, such as acute toxicity, carcinogenicity, mutagenicity, and
immunosuppression. The identification and targeting of specific mycotoxins have led to the
development of several diagnostic and therapeutic applications. GeneMedi’s anti-small molecule
antibodies and small molecules competitive antigens products can revolutionize mycotoxin
diagnostics and therapeutics. This class of biologics has shown exceptional specificity and
efficacy in recognizing and neutralizing mycotoxins, thereby preventing their harmful effects on
human health.
The classification of mycotoxins can be based on their chemical structure and source. Major
categories of mycotoxins include aflatoxins, trichothecenes, ochratoxins, and zearalenone, among
others. Each category comprises several important proteins with distinct functions and
therapeutic applications. Aflatoxins, produced by Aspergillus species, can cause liver cancer in
humans and animals. GeneMedi’s anti-small molecule antibodies and small molecules competitive
antigens product can be used for detecting and quantifying aflatoxins and developing therapeutic
interventions, such as immunotherapy, for the prevention and treatment of aflatoxin poisoning.
Trichothecenes, produced by Fusarium species, can cause vomiting, diarrhea, and oral lesions in
humans and animals. GeneMedi’s product can be used for the detection and quantification of
trichothecenes and developing therapeutic interventions, such as monoclonal antibodies, for the
prevention and treatment of trichothecene poisoning. Ochratoxins, produced by Aspergillus and
Penicillium species, can cause kidney damage and cancer in humans and animals. GeneMedi’s
product can be used for the detection and quantification of ochratoxins and developing
therapeutic interventions, such as competitive inhibitors, for the prevention and treatment of
ochratoxin poisoning.
Overall, GeneMedi’s anti-small molecule antibodies and small molecules competitive antigens
products offer extensive potential in the field of mycotoxin diagnostics and therapeutics. The
identification and targeting of specific mycotoxins offer opportunities for precision medicine
and personalized therapies. GeneMedi’s product has the potential to revolutionize the way we
diagnose and treat mycotoxin poisoning, thereby improving patient outcomes and quality of life.
GeneMedi's product can detect the small molecules of MYCOTOXINS from different samples using
ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay,
Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immunoassay (TINIA),
immunonephelometry, and POCT, which greatly enhances the sensitivity, specificity, and accuracy
of mycotoxin detection.
Drugs of Abuse
Drugs of abuse are chemical substances capable of altering mood, behavior, and perception,
resulting in addiction and severe health consequences. The detection and targeting of specific
drugs of abuse have led to the development of various diagnostic and therapeutic applications.
To this end, GeneMedi's anti-small molecule antibodies and small molecules competitive antigens
product exhibit immense potential in revolutionizing drugs of abuse diagnostics and
therapeutics. These biologics demonstrate high specificity and efficacy in detecting and
neutralizing drugs of abuse while mitigating their detrimental effects on human health.
Classification-wise, drugs of abuse can be categorized into opioids, stimulants, cannabinoids,
and other classes, each containing several proteins with distinct functions and therapeutic
implications. Opioids, for instance, refer to a diverse range of compounds, including
prescription pain relievers like oxycodone, hydrocodone, and fentanyl, as well as illicit drugs
such as heroin. GeneMedi's product can facilitate the development of diagnostic assays for
detecting and quantifying opioids. Therapeutic interventions such as monoclonal antibodies can
also be generated for the prevention and treatment of opioid addiction and overdose. Similarly,
stimulant drugs like cocaine, methamphetamine, and MDMA can be detected and targeted through
diagnostic assays based on GeneMedi's product. Competitive inhibitors can also be developed for
therapeutic interventions aimed at mitigating stimulant addiction and overdose. Cannabinoids,
which include marijuana and synthetic cannabinoids, present an additional class of drugs of
abuse that GeneMedi's product can detect and quantify. Immunotherapy can also be developed for
cannabinoid addiction and overdose prevention and treatment purposes.
GeneMedi's anti-small molecule antibodies and small molecules competitive antigens product offer
significant potential in drugs of abuse diagnostics and therapeutics. The identification and
classification of specific drugs of abuse open up opportunities for personalized therapies and
precision medicine. Apart from detecting drugs of abuse from different samples, GeneMedi's
product can benefit from various diagnostic assays, including ELISA, lateral flow immunoassay
(LFIA), colloidal gold immunochromatographic assay, chemiluminescent immunoassay (CLIA),
turbidimetric inhibition immunoassay (TINIA), immunonephelometry, and POCT. As such, the product
has the potential to transform the diagnosis and treatment of drug addiction and overdose,
ultimately improving patient outcomes and quality of life.
Toxic Heavy Metal
Toxic heavy metals are chemical elements that can cause severe health problems when present in
the environment or absorbed by the human body. The development of highly specific and effective
diagnostic and therapeutic applications targeting specific toxic heavy metals is of great
importance. GeneMedi's anti-small molecule antibodies and small molecules competitive antigens
products have shown significant potential in revolutionizing toxic heavy metal diagnostics and
therapeutics. These biologics have demonstrated high specificity and effectiveness in
recognizing and neutralizing toxic heavy metals, mitigating their harmful effects on human
health. Toxic heavy metals can be classified into various categories, including lead, mercury,
cadmium, and arsenic, among others. Each category comprises several important proteins with
unique functions and therapeutic applications.
Lead is a heavy metal that can cause damage to the nervous system, kidneys, and reproductive
system. GeneMedi's anti-small molecule antibodies and small molecules competitive antigens
product can be utilized in the development of diagnostic assays for the detection and
quantification of lead. It can also be used in the development of therapeutic interventions,
such as chelation therapy, for the prevention and treatment of lead poisoning. Mercury is a
heavy metal that can damage the brain, lungs, and kidneys. GeneMedi's product can be used to
develop diagnostic assays for detecting and quantifying mercury, as well as developing
therapeutic interventions, such as antioxidants, for preventing and treating mercury toxicity.
Cadmium is a heavy metal that can damage the kidneys and bones. GeneMedi's product offers
potential in the development of diagnostic assays for detecting and quantifying cadmium, and in
developing therapeutic interventions, such as metallothionein inducers, for the prevention and
treatment of cadmium toxicity. Arsenic is a heavy metal that can cause skin lesions, cancer, and
cardiovascular disease. GeneMedi's product can be used in developing diagnostic assays for the
detection and quantification of arsenic, as well as in developing therapeutic interventions,
such as competitive inhibitors, for the prevention and treatment of arsenic toxicity.
GeneMedi's anti-small molecule antibodies and small molecules competitive antigens products
offer significant potential in the field of toxic heavy metal diagnostics and therapeutics. The
classification and identification of specific toxic heavy metals present opportunities for
precision medicine and personalized therapies. GeneMedi's product has the potential to
revolutionize the way we diagnose and treat heavy metal toxicity, leading to better patient
outcomes and improved quality of life.
Detection of small molecules of toxic heavy metals from different samples can benefit from
various diagnostic assays. These include ELISA, Lateral flow immunoassay (LFIA), colloidal gold
immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition
immunoassay (TINIA), immunonephelometry, and POCT. GeneMedi's product's high specificity can
enable accurate detection and quantification of toxic heavy metal small molecules in these
diagnostic assays, contributing significantly to effective and precise diagnosis and treatment
of heavy metal toxicity.
Hormones
Hormones represent a class of chemical messengers secreted by endocrine glands that regulate
various physiological processes in the body. Hormones are categorized into several groups,
including steroid hormones, peptide and protein hormones, and amino acid derivatives based on
their structure and function. The identification and targeting of specific hormones have enabled
the development of several diagnostic and therapeutic applications for hormonal disorders.
GeneMedi's anti-small molecule antibodies and small molecules competitive antigens products hold
significant potential in revolutionizing hormone diagnostics and therapeutics. This class of
biologics has been demonstrated to be highly specific and effective in recognizing and
neutralizing hormones, thereby modulating their effects on human health.
GeneMedi's product can be used to develop diagnostic assays for the detection and quantification
of steroid hormones, such as testosterone, estrogen, and cortisol. Moreover, it can also be
applied in the development of therapeutic interventions, such as hormone replacement therapy,
for the prevention and treatment of hormonal imbalances. Peptide and protein hormones, such as
insulin, growth hormone, and follicle-stimulating hormone, constitute another group of important
hormones. GeneMedi's product can assist in the detection and quantification of peptide and
protein hormones, and the development of therapeutic interventions, such as monoclonal
antibodies, to prevent and treat hormonal disorders. The third category of hormones includes
amino acid derivatives, such as adrenaline and thyroxine. GeneMedi's product can facilitate the
development of diagnostic assays for detecting and quantifying amino acid derivative hormones,
and the development of therapeutic interventions, such as receptor antagonists, for the
prevention and treatment of hormonal disorders.
GeneMedi's anti-small molecule antibodies and small molecules competitive antigens products
present significant potential for revolutionizing hormone diagnostics and therapeutics. The
classification and identification of specific hormones offer opportunities for precision
medicine and personalized therapies. An accurate diagnosis of hormonal disorders is essential
for effective treatment, which GeneMedi's product can help achieve. The detection and
quantification of small molecules of HORMONE from different samples can be performed using
several assays, including ELISA, Lateral flow immunoassay (LFIA), colloidal gold
immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition
immunoassay (TINIA), immunonephelometry, and POCT. GeneMedi's product has the potential to
transform hormone diagnostics and therapeutics, contributing significantly to improved patient
outcomes and quality of life.
Chemicals
Chemicals are substances that possess a unique molecular composition and can be either naturally
occurring or artificially synthesized. The identification and targeting of specific chemicals
have led to the development of various diagnostic and therapeutic applications. GeneMedi's
anti-small molecule antibodies and small molecules competitive antigens products have a
remarkable potential to revolutionize chemical diagnostics and therapeutics. This class of
biologics has been shown to be highly specific and effective in recognizing and neutralizing
chemicals and modulating their effects on human health. Chemicals can be classified into several
categories, including organic and inorganic compounds, elements, and minerals, among others.
Each category comprises several important proteins with unique functions and therapeutic
implications. Organic compounds are compounds that contain carbon, such as carbohydrates,
lipids, and proteins. GeneMedi's anti-small molecule antibodies and small molecules competitive
antigens product can be used for developing diagnostic assays to detect and quantify organic
compounds and therapeutic interventions, like enzyme inhibitors, to prevent and treat diseases
caused by organic compounds. Inorganic compounds are compounds that do not contain carbon, such
as metals and metal oxides. GeneMedi's product can be used for developing diagnostic assays to
detect and quantify inorganic compounds and therapeutic interventions, such as chelation
therapy, to prevent and treat diseases caused by inorganic compounds. Elements like lead and
mercury are naturally occurring chemicals that can cause severe health problems when present in
the environment or absorbed by the human body. GeneMedi's product can be used for developing
diagnostic assays to detect and quantify elements and therapeutic interventions like metal
chelators, to prevent and treat diseases caused by elements.
Overall, GeneMedi’s anti-small molecule antibodies and small molecules competitive antigens
products offer significant potential in the field of chemical diagnostics and therapeutics. The
classification and identification of specific chemicals offer opportunities for precision
medicine and personalized therapies. GeneMedi's product can revolutionize the way we diagnose
and treat diseases caused by chemicals, thereby improving patient outcomes and quality of life.
GeneMedi has developed the antigen and antibody to detect various small molecules of CHEMICALS.
The detection and quantification of small molecules of chemicals from different samples can
benefit from several diagnostic assays like ELISA, Lateral flow immunoassay (LFIA), colloidal
gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition
immunoassay (TINIA), immunonephelometry, and POCT.
Vitamins
Vitamins are a group of organic compounds that are essential for normal physiological function
and must be obtained through diet or supplements. Specific vitamins play critical roles in
various metabolic pathways, and their deficiencies or excesses can lead to several diseases. The
identification and targeting of specific vitamins have led to the development of numerous
diagnostic and therapeutic applications. GeneMedi's anti-small molecule antibodies and small
molecules competitive antigens products can revolutionize vitamin diagnostics and therapeutics.
This class of biologics has been shown to be highly specific and effective in recognizing and
neutralizing vitamins, as well as modulating their effects on human health.
The two categories of vitamins are fat-soluble and water-soluble. Fat-soluble vitamins, such as
vitamins A, D, E, and K, are stored in the body's fatty tissues and liver, and their excess
accumulation can lead to toxicity. On the other hand, water-soluble vitamins, such as vitamins B
and C, are not stored in the body and must be replenished regularly. GeneMedi's anti-small
molecule antibodies and small molecules competitive antigens product can be utilized in
developing diagnostic assays for the detection and quantification of both fat-soluble and
water-soluble vitamins, as well as in developing therapeutic interventions, such as receptor
agonists and enzyme inhibitors, for the prevention and treatment of diseases caused by vitamin
deficiencies or excesses.
Overall, GeneMedi's anti-small molecule antibodies and small molecules competitive antigens
products offer significant potential in the field of vitamin diagnostics and therapeutics.
Specific vitamin identification and classification pave the way for precision medicine and
personalized therapies. GeneMedi's product has the potential to revolutionize the way we
diagnose and treat diseases caused by vitamin deficiencies or excesses, leading to better
patient outcomes and improved quality of life. Detecting the small molecules of vitamins from
different samples using diagnostic assays like ELISA, Lateral flow immunoassay (LFIA), colloidal
gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition
immunoassay (TINIA), immunonephelometry, and POCT can be facilitated using GeneMedi's antigen
and antibody technology.
Amino Acids
Amino acids are essential for the structure and function of cells, serving as the building blocks
of proteins. The discovery of specific amino acids has led to the development of various
diagnostic and therapeutic applications. GeneMedi's anti-small molecule antibodies and small
molecule competitive antigens have revolutionized the field of amino acid diagnostics and
therapeutics by offering a class of biologics that is highly specific and effective in
recognizing and neutralizing amino acids, as well as modulating their effects on human
health.
Amino acids can be classified into several categories, including essential and non-essential
amino acids, as well as branched-chain amino acids (BCAAs), each with distinct functions and
therapeutic applications. Essential amino acids cannot be produced by the body and must be
obtained through dietary intake or supplements. GeneMedi's anti-small molecule antibodies and
small molecule competitive antigens product can detect and quantify essential amino acids,
making them ideal for developing diagnostic assays and therapeutic interventions, such as enzyme
inhibitors, for the prevention and treatment of diseases caused by deficiencies of these amino
acids. Non-essential amino acids can be synthesized by the body and do not need to be obtained
through dietary intake or supplements. GeneMedi's product can detect and quantify non-essential
amino acids, which is useful for developing diagnostic assays and therapeutic interventions,
such as receptor agonists, for the prevention and treatment of diseases caused by imbalances of
these amino acids. BCAAs are critical for protein synthesis and muscle metabolism. GeneMedi's
product can detect and quantify BCAAs, making it useful for developing diagnostic assays and
therapeutic interventions, such as muscle-building supplements and metabolic modulators, for the
prevention and treatment of diseases caused by imbalances of these amino acids.
GeneMedi's anti-small molecule antibodies and small molecule competitive antigens products offer
significant potential in the field of amino acid diagnostics and therapeutics. The
classification and identification of specific amino acids offer opportunities for precision
medicine and personalized therapies, which can improve patient outcomes and quality of life.
GeneMedi's antigen and antibody technology can be used in various diagnostic assays, including
ELISA, lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay,
chemiluminescent immunoassay (CLIA), turbidimetric inhibition immunoassay (TINIA),
immunonephelometry, and POCT, for detecting small molecules of amino acids from different
samples.
IVD
Introdution-Food safety and small molecule detection
Food can transmit disease from person to person by serving as a growth medium for food contaminations that can cause food poisoning. Food safety refers to non-toxic, harmless of food, in line with the nutritional requirements, and does not cause any acute, subacute or chronic hazards on human health. Currently, food safety is a growing concern all over the world especially in developing areas. Ensuring the safety of food has become a significant challenge due to globalization of the food supply and the demand for minimally processed food products. Some potential sources for chemical and biological contamination of foods include: the use of pesticides, fertilizers, and antibiotics around agricultural food products; accidental introduction of additives to industrially processed foods at unsafe levels, or intentional adulteration with low quality or unsafe ingredients for economic purposes; cross-contamination with allergens or other substances that can be dangerous to sensitive individuals (e.g., wheat gluten); microbial growth deriving from unsanitary agricultural or processing conditions; and spoilage during transport and storage of foods due to packaging defects or incorrect handling by consumers. To manage food safety risks, there is a continued need for rapid, sensitive, inexpensive, and reliable techniques to detect the presence of chemical contaminants and microbes in complex media.
Food Safety Solutions
Food testing and analyzing plays an important role in quality control of food production.
  1. Culture-based traditional techniques
Traditional culture methods use selective liquid or solid culture media to grow, isolate, and enumerate target microorganism and simultaneously prevent the growth of other microorganisms present in the food (Jasson et al., 2010). These methods for the identification of foodborne pathogens involve pre-enrichment growth, selective enrichment culture, and selective plating followed by biochemical identification and serological confirmation of results. These methods are relatively inexpensive, sensitive, and still regarded as gold standards, the main drawback of these methods is their long analysis time and labor intensiveness. The whole procedure takes typically between 7 and 10 days (Vunrcrzant and Pllustoesser, 1987; Biswas, 2005).
  2. Mircoscopic and optical characteristics based methods
Various methods based on microscopic and optical characteristics of the appropriately stained microbial cells have been developed for assuring microbial safety of foods and food products. These methods include Direct Epifluorescent Filter Technique (DEFT), Flow Cytometry, and Solid Phase Cytometry. DEFT is a rapid method for enumerating microbial foodborne pathogens and is used widely in the dairy industry for raw foods (Hermida et al., 2000), milk and milk products, beverages, foods, etc. Flow cytometry is applied for the enumeration of viable bacteria in a sample, and uses flourescent dyes for the analysis of viability, metabolic state, and antigenic markers of bacteria. Solid-phase cytometry (SPC) combines the principles of epifluorescence microscopy and flow cytometry.
  3. Immunological methods
All immunological methods for the detection of foodborne pathogens are based on antigen–antibody reactions. The body produces specific antibodies in response to invading pathogen. These reactions are versatile and specific but the success of an immunoassay depends on the specificity of antibody. Various kits have been developed based on immunological methods for the detection of foodborne pathogens, and are available commercially and have been responsible for revolutionizing the field of food testing (Table 1).
  4. Nucleic acid-based methods
Spurred by technological developments and commercial profit motives, nucleic acid-based assays have become widely available as powerful tools to assist in the diagnosis and monitoring of foodborne pathogens. These methods are based on the detection of specific gene sequences (signature sequences) in the genotype of target organism. The sequences may be selected in such a way that they can detect a particular group, genus, species, or even the strain of microorganism. There are many DNA-based assay formats, but probes and nucleic acid amplification techniques are the most popular ones and have been developed commercially for detecting foodborne pathogens.
  5. Mass spectrometry
For years, mass spectrometry has been considered the most suitable analytical technique for the detection of multiple compounds in food, feed and water. Coupled to liquid chromatography (LC), high-performance LC and ultra-high performance LC (HPLC, UHPLC) or gas chromatographic (GC) separation with an ionization source such as electrospray (ESI), a large number of mass spectrometry-based methods were developed to comply with updated regulations. To effectively apply this approach, the structure of the compound must be characterized before its detection. Methods development can be time-consuming, and standards must be acquired to optimize compound-specific instrumental conditions, including transition selections, ion-source voltages, and collision energies. MRM methods are, therefore, unable to screen for unknown compounds
Small molecule detection-Hapten based competitive immunoassay
Small molecules such as pesticides, drugs, etc. are usually nonimmunogenic and hence do not elicit an immune response unless coupled with some macromolecules such as proteins. It is, therefore, required to modify these small substances (hapten) for coupling with macromolecules (carrier) so as to make a stable carrierhapten complex. Synthesis of hapten for linking with carrier proteins is the most important aspect of specific antibody generation against small molecules for immunoassay applications.